8YNI

Structure of the FADD/Caspase-8/cFLIP death effector domain assembly

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Caspase-8 subunit p10	polymer	479	55191.6	3	UniProt (Q14790) Pfam (PF01335) Pfam (PF00656)	Homo sapiens (human)
2	D, E, F, G, K (H, I, J, K, G)	CASP8 and FADD-like apoptosis regulator subunit p43	polymer	181	20878.5	5	UniProt (O15519) Pfam (PF01335)	Homo sapiens (human)	cFLIP
3	H, I, J (L, R, Q)	FAS-associated death domain protein	polymer	216	24291.4	3	UniProt (Q13158) Pfam (PF01335) Pfam (PF00531)	Homo sapiens (human)	FAS-associating death domain-containing protein,Growth-inhibiting gene 3 protein,Mediator of receptor induced toxicity

Sequence modifications

A, B, C: 1 - 479 (UniProt: Q14790)

PDB	External Database	Details
Gly 122	Phe 122	engineered mutation
Gly 123	Leu 123	engineered mutation
Ala 360	Cys 360	engineered mutation
Ala 374	Asp 374	engineered mutation
Ala 384	Asp 384	engineered mutation

L, R, Q: 1 - 208 (UniProt: Q13158)

PDB	External Database	Details
Gly 25	Phe 25	engineered mutation
Leu 209	-	expression tag
Glu 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	342841.6
All*	Total formula weight	342841.6

*Water molecules are not included.