8YNI

Structure of the FADD/Caspase-8/cFLIP death effector domain assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001817	biological_process	regulation of cytokine production
A	0002682	biological_process	regulation of immune system process
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005123	molecular_function	death receptor binding
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0007507	biological_process	heart development
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
A	0009967	biological_process	positive regulation of signal transduction
A	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
A	0016485	biological_process	protein processing
A	0016787	molecular_function	hydrolase activity
A	0030027	cellular_component	lamellipodium
A	0030101	biological_process	natural killer cell activation
A	0030154	biological_process	cell differentiation
A	0030225	biological_process	macrophage differentiation
A	0030335	biological_process	positive regulation of cell migration
A	0031264	cellular_component	death-inducing signaling complex
A	0031265	cellular_component	CD95 death-inducing signaling complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032025	biological_process	response to cobalt ion
A	0032355	biological_process	response to estradiol
A	0032496	biological_process	response to lipopolysaccharide
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032991	cellular_component	protein-containing complex
A	0034612	biological_process	response to tumor necrosis factor
A	0035877	molecular_function	death effector domain binding
A	0036462	biological_process	TRAIL-activated apoptotic signaling pathway
A	0042110	biological_process	T cell activation
A	0042113	biological_process	B cell activation
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043009	biological_process	chordate embryonic development
A	0043065	biological_process	positive regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044297	cellular_component	cell body
A	0044877	molecular_function	protein-containing complex binding
A	0045088	biological_process	regulation of innate immune response
A	0045471	biological_process	response to ethanol
A	0045651	biological_process	positive regulation of macrophage differentiation
A	0045862	biological_process	positive regulation of proteolysis
A	0048513	biological_process	animal organ development
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0051604	biological_process	protein maturation
A	0060546	biological_process	negative regulation of necroptotic process
A	0060715	biological_process	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
A	0070269	biological_process	pyroptotic inflammatory response
A	0071260	biological_process	cellular response to mechanical stimulus
A	0072347	biological_process	response to anesthetic
A	0097110	molecular_function	scaffold protein binding
A	0097190	biological_process	apoptotic signaling pathway
A	0097191	biological_process	extrinsic apoptotic signaling pathway
A	0097194	biological_process	execution phase of apoptosis
A	0097264	biological_process	self proteolysis
A	0097342	cellular_component	ripoptosome
A	1900119	biological_process	positive regulation of execution phase of apoptosis
B	0001525	biological_process	angiogenesis
B	0001817	biological_process	regulation of cytokine production
B	0002682	biological_process	regulation of immune system process
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005123	molecular_function	death receptor binding
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0007507	biological_process	heart development
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
B	0009967	biological_process	positive regulation of signal transduction
B	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
B	0016485	biological_process	protein processing
B	0016787	molecular_function	hydrolase activity
B	0030027	cellular_component	lamellipodium
B	0030101	biological_process	natural killer cell activation
B	0030154	biological_process	cell differentiation
B	0030225	biological_process	macrophage differentiation
B	0030335	biological_process	positive regulation of cell migration
B	0031264	cellular_component	death-inducing signaling complex
B	0031265	cellular_component	CD95 death-inducing signaling complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032025	biological_process	response to cobalt ion
B	0032355	biological_process	response to estradiol
B	0032496	biological_process	response to lipopolysaccharide
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032991	cellular_component	protein-containing complex
B	0034612	biological_process	response to tumor necrosis factor
B	0035877	molecular_function	death effector domain binding
B	0036462	biological_process	TRAIL-activated apoptotic signaling pathway
B	0042110	biological_process	T cell activation
B	0042113	biological_process	B cell activation
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043009	biological_process	chordate embryonic development
B	0043065	biological_process	positive regulation of apoptotic process
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0044297	cellular_component	cell body
B	0044877	molecular_function	protein-containing complex binding
B	0045088	biological_process	regulation of innate immune response
B	0045471	biological_process	response to ethanol
B	0045651	biological_process	positive regulation of macrophage differentiation
B	0045862	biological_process	positive regulation of proteolysis
B	0048513	biological_process	animal organ development
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0051604	biological_process	protein maturation
B	0060546	biological_process	negative regulation of necroptotic process
B	0060715	biological_process	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
B	0070269	biological_process	pyroptotic inflammatory response
B	0071260	biological_process	cellular response to mechanical stimulus
B	0072347	biological_process	response to anesthetic
B	0097110	molecular_function	scaffold protein binding
B	0097190	biological_process	apoptotic signaling pathway
B	0097191	biological_process	extrinsic apoptotic signaling pathway
B	0097194	biological_process	execution phase of apoptosis
B	0097264	biological_process	self proteolysis
B	0097342	cellular_component	ripoptosome
B	1900119	biological_process	positive regulation of execution phase of apoptosis
C	0001525	biological_process	angiogenesis
C	0001817	biological_process	regulation of cytokine production
C	0002682	biological_process	regulation of immune system process
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0005123	molecular_function	death receptor binding
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0007507	biological_process	heart development
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
C	0009967	biological_process	positive regulation of signal transduction
C	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
C	0016485	biological_process	protein processing
C	0016787	molecular_function	hydrolase activity
C	0030027	cellular_component	lamellipodium
C	0030101	biological_process	natural killer cell activation
C	0030154	biological_process	cell differentiation
C	0030225	biological_process	macrophage differentiation
C	0030335	biological_process	positive regulation of cell migration
C	0031264	cellular_component	death-inducing signaling complex
C	0031265	cellular_component	CD95 death-inducing signaling complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032025	biological_process	response to cobalt ion
C	0032355	biological_process	response to estradiol
C	0032496	biological_process	response to lipopolysaccharide
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0032991	cellular_component	protein-containing complex
C	0034612	biological_process	response to tumor necrosis factor
C	0035877	molecular_function	death effector domain binding
C	0036462	biological_process	TRAIL-activated apoptotic signaling pathway
C	0042110	biological_process	T cell activation
C	0042113	biological_process	B cell activation
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043009	biological_process	chordate embryonic development
C	0043065	biological_process	positive regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0044297	cellular_component	cell body
C	0044877	molecular_function	protein-containing complex binding
C	0045088	biological_process	regulation of innate immune response
C	0045471	biological_process	response to ethanol
C	0045651	biological_process	positive regulation of macrophage differentiation
C	0045862	biological_process	positive regulation of proteolysis
C	0048513	biological_process	animal organ development
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0051604	biological_process	protein maturation
C	0060546	biological_process	negative regulation of necroptotic process
C	0060715	biological_process	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
C	0070269	biological_process	pyroptotic inflammatory response
C	0071260	biological_process	cellular response to mechanical stimulus
C	0072347	biological_process	response to anesthetic
C	0097110	molecular_function	scaffold protein binding
C	0097190	biological_process	apoptotic signaling pathway
C	0097191	biological_process	extrinsic apoptotic signaling pathway
C	0097194	biological_process	execution phase of apoptosis
C	0097264	biological_process	self proteolysis
C	0097342	cellular_component	ripoptosome
C	1900119	biological_process	positive regulation of execution phase of apoptosis
G	0042981	biological_process	regulation of apoptotic process
H	0042981	biological_process	regulation of apoptotic process
I	0042981	biological_process	regulation of apoptotic process
J	0042981	biological_process	regulation of apoptotic process
K	0042981	biological_process	regulation of apoptotic process
L	0001819	biological_process	positive regulation of cytokine production
L	0001822	biological_process	kidney development
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002020	molecular_function	protease binding
L	0002376	biological_process	immune system process
L	0002821	biological_process	positive regulation of adaptive immune response
L	0005123	molecular_function	death receptor binding
L	0005164	molecular_function	tumor necrosis factor receptor binding
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006915	biological_process	apoptotic process
L	0006952	biological_process	defense response
L	0007165	biological_process	signal transduction
L	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
L	0009898	cellular_component	cytoplasmic side of plasma membrane
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0031264	cellular_component	death-inducing signaling complex
L	0031265	cellular_component	CD95 death-inducing signaling complex
L	0032729	biological_process	positive regulation of type II interferon production
L	0032757	biological_process	positive regulation of interleukin-8 production
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0032813	molecular_function	tumor necrosis factor receptor superfamily binding
L	0032991	cellular_component	protein-containing complex
L	0033077	biological_process	T cell differentiation in thymus
L	0033612	molecular_function	receptor serine/threonine kinase binding
L	0035591	molecular_function	signaling adaptor activity
L	0035877	molecular_function	death effector domain binding
L	0036462	biological_process	TRAIL-activated apoptotic signaling pathway
L	0042104	biological_process	positive regulation of activated T cell proliferation
L	0042220	biological_process	response to cocaine
L	0042802	molecular_function	identical protein binding
L	0042981	biological_process	regulation of apoptotic process
L	0043029	biological_process	T cell homeostasis
L	0043065	biological_process	positive regulation of apoptotic process
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0044297	cellular_component	cell body
L	0044877	molecular_function	protein-containing complex binding
L	0045087	biological_process	innate immune response
L	0045089	biological_process	positive regulation of innate immune response
L	0045651	biological_process	positive regulation of macrophage differentiation
L	0045862	biological_process	positive regulation of proteolysis
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0048148	biological_process	behavioral response to cocaine
L	0048535	biological_process	lymph node development
L	0048536	biological_process	spleen development
L	0048538	biological_process	thymus development
L	0050778	biological_process	positive regulation of immune response
L	0051607	biological_process	defense response to virus
L	0051707	biological_process	response to other organism
L	0060340	biological_process	positive regulation of type I interferon-mediated signaling pathway
L	0060544	biological_process	regulation of necroptotic process
L	0070236	biological_process	negative regulation of activation-induced cell death of T cells
L	0071260	biological_process	cellular response to mechanical stimulus
L	0071550	biological_process	death-inducing signaling complex assembly
L	0089720	molecular_function	caspase binding
L	0097190	biological_process	apoptotic signaling pathway
L	0097191	biological_process	extrinsic apoptotic signaling pathway
L	0097342	cellular_component	ripoptosome
L	0097527	biological_process	necroptotic signaling pathway
L	1900119	biological_process	positive regulation of execution phase of apoptosis
L	2000454	biological_process	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
L	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway
Q	0001819	biological_process	positive regulation of cytokine production
Q	0001822	biological_process	kidney development
Q	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
Q	0002020	molecular_function	protease binding
Q	0002376	biological_process	immune system process
Q	0002821	biological_process	positive regulation of adaptive immune response
Q	0005123	molecular_function	death receptor binding
Q	0005164	molecular_function	tumor necrosis factor receptor binding
Q	0005515	molecular_function	protein binding
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0006915	biological_process	apoptotic process
Q	0006952	biological_process	defense response
Q	0007165	biological_process	signal transduction
Q	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
Q	0009898	cellular_component	cytoplasmic side of plasma membrane
Q	0030674	molecular_function	protein-macromolecule adaptor activity
Q	0031264	cellular_component	death-inducing signaling complex
Q	0031265	cellular_component	CD95 death-inducing signaling complex
Q	0032729	biological_process	positive regulation of type II interferon production
Q	0032757	biological_process	positive regulation of interleukin-8 production
Q	0032760	biological_process	positive regulation of tumor necrosis factor production
Q	0032813	molecular_function	tumor necrosis factor receptor superfamily binding
Q	0032991	cellular_component	protein-containing complex
Q	0033077	biological_process	T cell differentiation in thymus
Q	0033612	molecular_function	receptor serine/threonine kinase binding
Q	0035591	molecular_function	signaling adaptor activity
Q	0035877	molecular_function	death effector domain binding
Q	0036462	biological_process	TRAIL-activated apoptotic signaling pathway
Q	0042104	biological_process	positive regulation of activated T cell proliferation
Q	0042220	biological_process	response to cocaine
Q	0042802	molecular_function	identical protein binding
Q	0042981	biological_process	regulation of apoptotic process
Q	0043029	biological_process	T cell homeostasis
Q	0043065	biological_process	positive regulation of apoptotic process
Q	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
Q	0044297	cellular_component	cell body
Q	0044877	molecular_function	protein-containing complex binding
Q	0045087	biological_process	innate immune response
Q	0045089	biological_process	positive regulation of innate immune response
Q	0045651	biological_process	positive regulation of macrophage differentiation
Q	0045862	biological_process	positive regulation of proteolysis
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0048148	biological_process	behavioral response to cocaine
Q	0048535	biological_process	lymph node development
Q	0048536	biological_process	spleen development
Q	0048538	biological_process	thymus development
Q	0050778	biological_process	positive regulation of immune response
Q	0051607	biological_process	defense response to virus
Q	0051707	biological_process	response to other organism
Q	0060340	biological_process	positive regulation of type I interferon-mediated signaling pathway
Q	0060544	biological_process	regulation of necroptotic process
Q	0070236	biological_process	negative regulation of activation-induced cell death of T cells
Q	0071260	biological_process	cellular response to mechanical stimulus
Q	0071550	biological_process	death-inducing signaling complex assembly
Q	0089720	molecular_function	caspase binding
Q	0097190	biological_process	apoptotic signaling pathway
Q	0097191	biological_process	extrinsic apoptotic signaling pathway
Q	0097342	cellular_component	ripoptosome
Q	0097527	biological_process	necroptotic signaling pathway
Q	1900119	biological_process	positive regulation of execution phase of apoptosis
Q	2000454	biological_process	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
Q	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway
R	0001819	biological_process	positive regulation of cytokine production
R	0001822	biological_process	kidney development
R	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
R	0002020	molecular_function	protease binding
R	0002376	biological_process	immune system process
R	0002821	biological_process	positive regulation of adaptive immune response
R	0005123	molecular_function	death receptor binding
R	0005164	molecular_function	tumor necrosis factor receptor binding
R	0005515	molecular_function	protein binding
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006915	biological_process	apoptotic process
R	0006952	biological_process	defense response
R	0007165	biological_process	signal transduction
R	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
R	0009898	cellular_component	cytoplasmic side of plasma membrane
R	0030674	molecular_function	protein-macromolecule adaptor activity
R	0031264	cellular_component	death-inducing signaling complex
R	0031265	cellular_component	CD95 death-inducing signaling complex
R	0032729	biological_process	positive regulation of type II interferon production
R	0032757	biological_process	positive regulation of interleukin-8 production
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0032813	molecular_function	tumor necrosis factor receptor superfamily binding
R	0032991	cellular_component	protein-containing complex
R	0033077	biological_process	T cell differentiation in thymus
R	0033612	molecular_function	receptor serine/threonine kinase binding
R	0035591	molecular_function	signaling adaptor activity
R	0035877	molecular_function	death effector domain binding
R	0036462	biological_process	TRAIL-activated apoptotic signaling pathway
R	0042104	biological_process	positive regulation of activated T cell proliferation
R	0042220	biological_process	response to cocaine
R	0042802	molecular_function	identical protein binding
R	0042981	biological_process	regulation of apoptotic process
R	0043029	biological_process	T cell homeostasis
R	0043065	biological_process	positive regulation of apoptotic process
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0044297	cellular_component	cell body
R	0044877	molecular_function	protein-containing complex binding
R	0045087	biological_process	innate immune response
R	0045089	biological_process	positive regulation of innate immune response
R	0045651	biological_process	positive regulation of macrophage differentiation
R	0045862	biological_process	positive regulation of proteolysis
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0048148	biological_process	behavioral response to cocaine
R	0048535	biological_process	lymph node development
R	0048536	biological_process	spleen development
R	0048538	biological_process	thymus development
R	0050778	biological_process	positive regulation of immune response
R	0051607	biological_process	defense response to virus
R	0051707	biological_process	response to other organism
R	0060340	biological_process	positive regulation of type I interferon-mediated signaling pathway
R	0060544	biological_process	regulation of necroptotic process
R	0070236	biological_process	negative regulation of activation-induced cell death of T cells
R	0071260	biological_process	cellular response to mechanical stimulus
R	0071550	biological_process	death-inducing signaling complex assembly
R	0089720	molecular_function	caspase binding
R	0097190	biological_process	apoptotic signaling pathway
R	0097191	biological_process	extrinsic apoptotic signaling pathway
R	0097342	cellular_component	ripoptosome
R	0097527	biological_process	necroptotic signaling pathway
R	1900119	biological_process	positive regulation of execution phase of apoptosis
R	2000454	biological_process	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
R	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HsnmdCfiCcILSHG

Chain	Residue	Details
A	HIS304-GLY318

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	522
Details	Domain: {"description":"DED 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	387
Details	Domain: {"description":"DED 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	234
Details	Domain: {"description":"DED","evidences":[{"source":"PROSITE-ProRule","id":"PRU00065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

---