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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8YN4

Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Engineered guanine nucleotide-binding protein G(q) subunit alphapolymer24628084.81synthetic construct
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37640845.61UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(E)		Antibody fragment scFv16polymer25527374.41synthetic construct
5E
(R)		Histamine H2 receptorpolymer56862465.41UniProt (P25021)
Pfam (PF00001)		Homo sapiens (human)H2R,HH2R,Gastric receptor I
6F
(R)		HISTAMINEnon-polymer111.11Chemie (HSM)
7G
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
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PubChem (369319)
PubChem (18640088)
PubChem (1715243)
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PubChem (40557614)
PubChem (42579431)
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PubChem (59450329)
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PubChem (66634651)
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PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
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PubChem (6419195)
PubChem (5997)
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PubChem (7059635)
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PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
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PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
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PubChem (124225449)
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PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
A: 1 - 65 (PDB: 8YN4)
A: 66 - 359 (PDB: 8YN4)
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -9-initiating methionine
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
R: 1 - 308 (UniProt: P25021)
PDBExternal DatabaseDetails
Asp -84-expression tag
Tyr -83-expression tag
Lys -82-expression tag
Asp -81-expression tag
Asp -80-expression tag
Asp -79-expression tag
Asp -78-expression tag
His -77-expression tag
His -76-expression tag
His -75-expression tag
His -74-expression tag
His -73-expression tag
His -72-expression tag
His -71-expression tag
His -70-expression tag
Gly -69-expression tag
Gln -68-expression tag
Pro -67-expression tag
Gly -66-expression tag
Asn -65-expression tag
Gly -64-expression tag
Ser -63-expression tag
Ala -62-expression tag
Phe -61-expression tag
Leu -60-expression tag
Leu -59-expression tag
Ala -58-expression tag
Pro -57-expression tag
Asn -56-expression tag
Gly -55-expression tag
Ser -54-expression tag
His -53-expression tag
Ala -52-expression tag
Pro -51-expression tag
Asp -50-expression tag
His -49-expression tag
Asn -48-expression tag
Val -47-expression tag
Thr -46-expression tag
Gln -45-expression tag
Gln -44-expression tag
Arg -43-expression tag
Asp -42-expression tag
Glu -41-expression tag
Gly -40-expression tag
Gly -39-expression tag
Ser -38-expression tag
Gly -37-expression tag
Gln -36-expression tag
Pro -35-expression tag
Gly -34-expression tag
Asn -33-expression tag
Gly -32-expression tag
Ser -31-expression tag
Ala -30-expression tag
Phe -29-expression tag
Leu -28-expression tag
Leu -27-expression tag
Ala -26-expression tag
Pro -25-expression tag
Asn -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
His -21-expression tag
Ala -20-expression tag
Pro -19-expression tag
Asp -18-expression tag
His -17-expression tag
Asn -16-expression tag
Val -15-expression tag
Thr -14-expression tag
Gln -13-expression tag
Gln -12-expression tag
Arg -11-expression tag
Asp -10-expression tag
Glu -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Val -1-expression tag
Asp 0-expression tag
R: 309 - 483 (PDB: 8YN4)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight166631.4
Non-Polymers*Number of molecules2
Total formula weight497.8
All*Total formula weight167129.2
*Water molecules are not included.

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PDB entries from 2026-04-01

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