8YN4
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLFMISLDRYCaV |
| Chain | Residue | Details |
| R | ALA104-VAL120 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 | |
| B | VAL327-GLY341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| R | MET1-THR22 | |
| R | CYS82-ASN92 | |
| R | SER160-GLU180 | |
| R | LEU259-GLU267 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL23-GLY44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU45-ILE57 | |
| R | ASP115-ARG134 | |
| R | ILE205-VAL234 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL58-SER81 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| R | ILE93-LEU114 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL135-ASN159 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL181-ARG204 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | THR235-GLY258 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL268-ALA289 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Essential for histamine binding => ECO:0000250 |
| Chain | Residue | Details |
| R | ASP98 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Essential for tiotidine binding and implicated in H2 selectivity => ECO:0000250 |
| Chain | Residue | Details |
| R | ASP186 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | SITE: Implicated in histamine binding => ECO:0000250 |
| Chain | Residue | Details |
| R | THR190 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| R | CYS305 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN4 |
