8YM7
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 660 | 73448.0 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A |
| 2 | B (B) | REST corepressor 1 | polymer | 134 | 15446.6 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | Homo sapiens (human) | Protein CoREST |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 4 | D (A) | 4-[5-(4-azanylpiperidin-1-yl)-8-(4-methylphenyl)pyrido[3,4-b]pyrazin-7-yl]-2-fluoranyl-benzenecarbonitrile | non-polymer | 438.5 | 1 | Chemie (A1LZJ) |
Sequence modifications
A: 173 - 832 (UniProt: O60341)
| PDB | External Database | Details |
|---|---|---|
| Ala 173 | Gly 173 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 88894.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1224.0 | |
| All* | Total formula weight | 90118.7 |
