8YM6
Structure of Caspase-8/cFLIP death effector domain assembly
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, B, A, D) | Caspase-8 subunit p10 | polymer | 185 | 22011.4 | 4 | UniProt (Q14790) Pfam (PF01335) | Homo sapiens (human) | |
| 2 | E, F, G, H, I... (H, G, F, K, I...) | CASP8 and FADD-like apoptosis regulator subunit p43 | polymer | 184 | 21160.8 | 9 | UniProt (O15519) Pfam (PF01335) | Homo sapiens (human) | cFLIP |
Sequence modifications
C, B, A, D: 1 - 185 (UniProt: Q14790)
H, G, F, K, I, J, M, O, N: 1 - 181 (UniProt: O15519)
| PDB | External Database | Details |
|---|---|---|
| Gly 122 | Phe 122 | engineered mutation |
| Gly 123 | Leu 123 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 278492.6 | |
| All* | Total formula weight | 278492.6 |
