8YM4
Structure of Caspase-8/cFLIP death effector domain assembly
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, J (C, B, D, A) | Caspase-8 | polymer | 185 | 22339.7 | 4 | UniProt (Q14790) Pfam (PF01335) | Homo sapiens (human) | CASP-8,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,ICE-like apoptotic protease 5,MORT1-associated ced-3 homolog,MACH |
| 2 | D, E, F, G, H... (H, G, F, K, I...) | CASP8 and FADD-like apoptosis regulator subunit p43 | polymer | 184 | 21361.0 | 6 | UniProt (O15519) Pfam (PF01335) | Homo sapiens (human) | cFLIP |
| 3 | K (F) | SELENIUM ATOM | non-polymer | 79.0 | 1 | Chemie (SE) | |||
| 4 | L, M, N, O, P... (C, B, D, G, K...) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
C, B, D, A: 1 - 185 (UniProt: Q14790)
H, G, F, K, I, J: 1 - 181 (UniProt: O15519)
| PDB | External Database | Details |
|---|---|---|
| Gly 122 | Phe 122 | engineered mutation |
| Gly 123 | Leu 123 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Gly 7 | His 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 217525.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 79.0 | |
| All* | Total formula weight | 217604.0 |
