8YKW
Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 3 | E | Antibody fragment ScFv16 | polymer | 247 | 26309.3 | 1 | synthetic construct | ||
| 4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (cattle) | G gamma-I |
| 5 | R | Succinate receptor 1 | polymer | 334 | 38729.7 | 1 | UniProt (Q9BXA5) Pfam (PF00001) In PDB | Homo sapiens (human) | G-protein coupled receptor 91,P2Y purinoceptor 1-like |
| 6 | R | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 150731.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 118.1 | |
| All* | Total formula weight | 150849.2 |
