8YKI

FGFR-1 in complex with ligand tasurgratinib

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 1	polymer	317	36116.5	2	UniProt (P11362) Pfam (PF07714)	Homo sapiens (human)	FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2	C, E (A, B)	Tasurgratinib	non-polymer		587.7	2	Chemie (A1LY1)
3	D, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	G, H (A, B)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B: 461 - 774 (UniProt: P11362)

PDB	External Database	Details
Gly 458	-	expression tag
Gly 459	-	expression tag
Ser 460	-	expression tag
Ala 488	Cys 488	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72232.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1246.2
All*	Total formula weight	73479.2

*Water molecules are not included.