8YI7
The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex, local refinement
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Interleukin-12 subunit alpha | polymer | 207 | 23781.5 | 1 | UniProt (P29459) Pfam (PF03039) In PDB | Homo sapiens (human) | IL-12A,Cytotoxic lymphocyte maturation factor 35 kDa subunit,CLMF p35,IL-12 subunit p35,NK cell stimulatory factor chain 1,NKSF1 |
2 | B | Interleukin-12 subunit beta | polymer | 307 | 34811.0 | 1 | UniProt (P29460) Pfam (PF10420) In PDB | Homo sapiens (human) | IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2 |
3 | C | Interleukin-12 receptor subunit beta-2 | polymer | 302 | 34627.5 | 1 | UniProt (Q99665) Pfam (PF06328) In PDB | Homo sapiens (human) | IL-12 receptor subunit beta-2,IL-12R subunit beta-2,IL-12R-beta-2,IL-12RB2 |
4 | D | Interleukin-12 receptor subunit beta-1 | polymer | 219 | 24736.4 | 1 | UniProt (P42701) In PDB | Homo sapiens (human) | IL-12 receptor subunit beta-1,IL-12R subunit beta-1,IL-12R-beta-1,IL-12RB1,IL-12 receptor beta component |
5 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
6 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 19 - 219 (UniProt: P29459)
C: 24 - 319 (UniProt: Q99665)
D: 24 - 236 (UniProt: P42701)
PDB | External Database | Details |
---|---|---|
His 220 | - | expression tag |
His 221 | - | expression tag |
His 222 | - | expression tag |
His 223 | - | expression tag |
His 224 | - | expression tag |
His 225 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 320 | - | expression tag |
His 321 | - | expression tag |
His 322 | - | expression tag |
His 323 | - | expression tag |
His 324 | - | expression tag |
His 325 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 237 | - | expression tag |
His 238 | - | expression tag |
His 239 | - | expression tag |
His 240 | - | expression tag |
His 241 | - | expression tag |
His 242 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 117956.5 | |
Branched | Number of molecules | 1 |
Total formula weight | 586.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 118764.2 |