8YI7

The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex, local refinement

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005143	molecular_function	interleukin-12 receptor binding
A	0005576	cellular_component	extracellular region
A	0006955	biological_process	immune response
A	0008083	molecular_function	growth factor activity
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. CFQDPPY

Chain	Residue	Details
D	CYS30-TYR36

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site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV

Chain	Residue	Details
B	ILE233-VAL275

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
D	ASN121
C	ASN129
C	ASN166
C	ASN195
C	ASN271

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10899108

Chain	Residue	Details
B	ASN222

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10207176

Chain	Residue	Details
B	TRP319

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