8YD7
Structure of FADD/Caspase-8/cFLIP death effector domain assembly
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | G, H, I, K | CASP8 and FADD-like apoptosis regulator subunit p12 | polymer | 181 | 21078.8 | 4 | UniProt (O15519) Pfam (PF01335) In PDB | Homo sapiens (human) | |
2 | D, C, B, E, A | Caspase-8 | polymer | 185 | 22339.7 | 5 | UniProt (Q14790) Pfam (PF01335) In PDB | Homo sapiens (human) | CASP-8,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,ICE-like apoptotic protease 5,MORT1-associated ced-3 homolog,MACH |
3 | L | FAS-associated death domain protein | polymer | 216 | 24534.9 | 1 | UniProt (Q13158) Pfam (PF01335) Pfam (PF00531) In PDB | Homo sapiens (human) | FAS-associating death domain-containing protein,Growth-inhibiting gene 3 protein,Mediator of receptor induced toxicity |
4 | G | SELENIUM ATOM | non-polymer | 79.0 | 1 | Chemie (SE) |
Sequence modifications
G, H, I, K: 1 - 181 (UniProt: O15519)
D, C, B, E, A: 1 - 185 (UniProt: Q14790)
L: 1 - 208 (UniProt: Q13158)
PDB | External Database | Details |
---|---|---|
Gly 7 | His 7 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 122 | Phe 122 | engineered mutation |
Gly 123 | Leu 123 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 9 | His 9 | engineered mutation |
Leu 209 | - | expression tag |
Glu 210 | - | expression tag |
His 211 | - | expression tag |
His 212 | - | expression tag |
His 213 | - | expression tag |
His 214 | - | expression tag |
His 215 | - | expression tag |
His 216 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 220548.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 79.0 | |
All* | Total formula weight | 220627.5 |