8YD7

Structure of FADD/Caspase-8/cFLIP death effector domain assembly

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F, G, H (G, H, I, K)	CASP8 and FADD-like apoptosis regulator subunit p12	polymer	181	21078.8	4	UniProt (O15519) Pfam (PF01335)	Homo sapiens (human)
2	B, C, D, E, J (D, C, B, E, A)	Caspase-8	polymer	185	22339.7	5	UniProt (Q14790) Pfam (PF01335)	Homo sapiens (human)	CASP-8,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,ICE-like apoptotic protease 5,MORT1-associated ced-3 homolog,MACH
3	I (L)	FAS-associated death domain protein	polymer	216	24534.9	1	UniProt (Q13158) Pfam (PF01335) Pfam (PF00531)	Homo sapiens (human)	FAS-associating death domain-containing protein,Growth-inhibiting gene 3 protein,Mediator of receptor induced toxicity
4	K (G)	SELENIUM ATOM	non-polymer		79.0	1	Chemie (SE)

Sequence modifications

G, H, I, K: 1 - 181 (UniProt: O15519)

PDB	External Database	Details
Gly 7	His 7	engineered mutation

D, C, B, E, A: 1 - 185 (UniProt: Q14790)

PDB	External Database	Details
Gly 122	Phe 122	engineered mutation
Gly 123	Leu 123	engineered mutation

L: 1 - 208 (UniProt: Q13158)

PDB	External Database	Details
Gly 9	His 9	engineered mutation
Leu 209	-	expression tag
Glu 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	220548.5
Non-Polymers*	Number of molecules	1
	Total formula weight	79.0
All*	Total formula weight	220627.5

*Water molecules are not included.