8YD7

Structure of FADD/Caspase-8/cFLIP death effector domain assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0042981	biological_process	regulation of apoptotic process
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0042981	biological_process	regulation of apoptotic process
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0042981	biological_process	regulation of apoptotic process
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0006915	biological_process	apoptotic process
E	0042981	biological_process	regulation of apoptotic process
G	0042981	biological_process	regulation of apoptotic process
H	0042981	biological_process	regulation of apoptotic process
I	0042981	biological_process	regulation of apoptotic process
K	0042981	biological_process	regulation of apoptotic process
L	0001819	biological_process	positive regulation of cytokine production
L	0001822	biological_process	kidney development
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002020	molecular_function	protease binding
L	0002376	biological_process	immune system process
L	0002821	biological_process	positive regulation of adaptive immune response
L	0005123	molecular_function	death receptor binding
L	0005164	molecular_function	tumor necrosis factor receptor binding
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006915	biological_process	apoptotic process
L	0006952	biological_process	defense response
L	0007165	biological_process	signal transduction
L	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
L	0009898	cellular_component	cytoplasmic side of plasma membrane
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0031264	cellular_component	death-inducing signaling complex
L	0031265	cellular_component	CD95 death-inducing signaling complex
L	0032729	biological_process	positive regulation of type II interferon production
L	0032757	biological_process	positive regulation of interleukin-8 production
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0032813	molecular_function	tumor necrosis factor receptor superfamily binding
L	0032991	cellular_component	protein-containing complex
L	0033077	biological_process	T cell differentiation in thymus
L	0033612	molecular_function	receptor serine/threonine kinase binding
L	0035591	molecular_function	signaling adaptor activity
L	0035877	molecular_function	death effector domain binding
L	0036462	biological_process	TRAIL-activated apoptotic signaling pathway
L	0042104	biological_process	positive regulation of activated T cell proliferation
L	0042220	biological_process	response to cocaine
L	0042802	molecular_function	identical protein binding
L	0042981	biological_process	regulation of apoptotic process
L	0043029	biological_process	T cell homeostasis
L	0043065	biological_process	positive regulation of apoptotic process
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0044297	cellular_component	cell body
L	0044877	molecular_function	protein-containing complex binding
L	0045087	biological_process	innate immune response
L	0045089	biological_process	positive regulation of innate immune response
L	0045651	biological_process	positive regulation of macrophage differentiation
L	0045862	biological_process	positive regulation of proteolysis
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0048148	biological_process	behavioral response to cocaine
L	0048535	biological_process	lymph node development
L	0048536	biological_process	spleen development
L	0048538	biological_process	thymus development
L	0050778	biological_process	positive regulation of immune response
L	0051607	biological_process	defense response to virus
L	0051707	biological_process	response to other organism
L	0060340	biological_process	positive regulation of type I interferon-mediated signaling pathway
L	0060544	biological_process	regulation of necroptotic process
L	0070236	biological_process	negative regulation of activation-induced cell death of T cells
L	0071260	biological_process	cellular response to mechanical stimulus
L	0071550	biological_process	death-inducing signaling complex assembly
L	0089720	molecular_function	caspase binding
L	0097190	biological_process	apoptotic signaling pathway
L	0097191	biological_process	extrinsic apoptotic signaling pathway
L	0097342	cellular_component	ripoptosome
L	0097527	biological_process	necroptotic signaling pathway
L	1900119	biological_process	positive regulation of execution phase of apoptosis
L	2000454	biological_process	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
L	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 818

Chain

Residue

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site_id	MCSA2
Number of Residues
Details	M-CSA 818

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Residue

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site_id	MCSA3
Number of Residues
Details	M-CSA 818

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Residue

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site_id	MCSA4
Number of Residues
Details	M-CSA 818

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Residue

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site_id	MCSA5
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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