8Y69

LGR4-RSPO2-ZNRF3 (2:2:2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, D)	Leucine-rich repeat-containing G-protein coupled receptor 4	polymer	788	87170.0	2	UniProt (Q9BXB1) Pfam (PF01462) Pfam (PF13855) Pfam (PF00001)	Homo sapiens (human)	G-protein coupled receptor 48
2	B, F (C, H)	E3 ubiquitin-protein ligase ZNRF3	polymer	188	20864.1	2	UniProt (Q9ULT6) Pfam (PF18212)	Homo sapiens (human)	RING finger protein 203,RING-type E3 ubiquitin transferase ZNRF3,Zinc/RING finger protein 3
3	C, G (E, I)	MB52	polymer	560	59692.8	2		Camelus bactrianus
4	D, H (G, J)	R-spondin-2	polymer	101	11631.4	2	UniProt (Q8BFU0) Pfam (PF15913) UniProt (by SIFTS) (Q6UXX9)	Homo sapiens (human)	Cysteine-rich and single thrombospondin domain-containing protein 2,Cristin-2,mCristin-2,Roof plate-specific spondin-2
5	I, J (D, H)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)

Sequence modifications

A, D: 33 - 820 (UniProt: Q9BXB1)

PDB	External Database	Details
Ala 78	Lys 78	conflict
Cys 566	Ser 566	conflict
Ala 567	Cys 567	conflict

G, J: 41 - 141 (UniProt: Q8BFU0)

PDB	External Database	Details
Ala 130	Asp 130	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	358716.6
Non-Polymers*	Number of molecules	2
	Total formula weight	773.3
All*	Total formula weight	359489.9

*Water molecules are not included.