8XVH
Cryo-EM structure of ETBR bound with Endothelin1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 261 | 30464.3 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 346 | 38045.6 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody 35 | polymer | 157 | 17057.3 | 1 | Lama glama | ||
| 5 | E (T) | Endothelin-1 | polymer | 21 | 2498.0 | 1 | UniProt (P05305) Pfam (PF00322) | Homo sapiens (human) | ET-1 |
| 6 | F (R) | Exo-alpha-sialidase,Endothelin receptor type B | polymer | 837 | 94123.8 | 1 | UniProt (Q59310) UniProt (P24530) Pfam (PF13859) Pfam (PF00001) | Clostridium perfringens | ET-B,ET-BR,Endothelin receptor non-selective type |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -385 - 66 (UniProt: Q59310)
R: 67 - 406 (UniProt: P24530)
| PDB | External Database | Details |
|---|---|---|
| Ile -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Phe 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -412 | - | initiating methionine |
| Lys -411 | - | expression tag |
| Thr -410 | - | expression tag |
| Ile -409 | - | expression tag |
| Ile -408 | - | expression tag |
| Ala -407 | - | expression tag |
| Leu -406 | - | expression tag |
| Ser -405 | - | expression tag |
| Tyr -404 | - | expression tag |
| Ile -403 | - | expression tag |
| Phe -402 | - | expression tag |
| Cys -401 | - | expression tag |
| Leu -400 | - | expression tag |
| Val -399 | - | expression tag |
| Phe -398 | - | expression tag |
| Ala -397 | - | expression tag |
| Asp -396 | - | expression tag |
| Tyr -395 | - | expression tag |
| Lys -394 | - | expression tag |
| Asp -393 | - | expression tag |
| Asp -392 | - | expression tag |
| Asp -391 | - | expression tag |
| Asp -390 | - | expression tag |
| Ala -389 | - | expression tag |
| Gly -388 | - | expression tag |
| Arg -387 | - | expression tag |
| Ala -386 | - | expression tag |
| Ser -235 | Gly 393 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 407 | - | expression tag |
| Glu 408 | - | expression tag |
| Val 409 | - | expression tag |
| Leu 410 | - | expression tag |
| Phe 411 | - | expression tag |
| Gln 412 | - | expression tag |
| Gly 413 | - | expression tag |
| Pro 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
| His 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 190050.1 | |
| All* | Total formula weight | 190050.1 |
