8XVH
Cryo-EM structure of ETBR bound with Endothelin1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 261 | 30464.3 | 1 | Homo sapiens (human) | ||
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 346 | 38045.6 | 1 | UniProt (P62873) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody 35 | polymer | 157 | 17057.3 | 1 | Lama glama | ||
5 | T | Endothelin-1 | polymer | 21 | 2498.0 | 1 | UniProt (P05305) In PDB | Homo sapiens (human) | ET-1 |
6 | R | Exo-alpha-sialidase,Endothelin receptor type B | polymer | 837 | 94123.8 | 1 | UniProt (Q59310) UniProt (P24530) In PDB | Clostridium perfringens | ET-B,ET-BR,Endothelin receptor non-selective type |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -385 - 66 (UniProt: Q59310)
R: 67 - 406 (UniProt: P24530)
PDB | External Database | Details |
---|---|---|
Ile -5 | - | expression tag |
Gly -4 | - | expression tag |
Arg -3 | - | expression tag |
Ala -2 | - | expression tag |
Arg -1 | - | expression tag |
Gly 0 | - | expression tag |
Phe 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -412 | - | initiating methionine |
Lys -411 | - | expression tag |
Thr -410 | - | expression tag |
Ile -409 | - | expression tag |
Ile -408 | - | expression tag |
Ala -407 | - | expression tag |
Leu -406 | - | expression tag |
Ser -405 | - | expression tag |
Tyr -404 | - | expression tag |
Ile -403 | - | expression tag |
Phe -402 | - | expression tag |
Cys -401 | - | expression tag |
Leu -400 | - | expression tag |
Val -399 | - | expression tag |
Phe -398 | - | expression tag |
Ala -397 | - | expression tag |
Asp -396 | - | expression tag |
Tyr -395 | - | expression tag |
Lys -394 | - | expression tag |
Asp -393 | - | expression tag |
Asp -392 | - | expression tag |
Asp -391 | - | expression tag |
Asp -390 | - | expression tag |
Ala -389 | - | expression tag |
Gly -388 | - | expression tag |
Arg -387 | - | expression tag |
Ala -386 | - | expression tag |
Ser -235 | Gly 393 | conflict |
PDB | External Database | Details |
---|---|---|
Leu 407 | - | expression tag |
Glu 408 | - | expression tag |
Val 409 | - | expression tag |
Leu 410 | - | expression tag |
Phe 411 | - | expression tag |
Gln 412 | - | expression tag |
Gly 413 | - | expression tag |
Pro 414 | - | expression tag |
His 415 | - | expression tag |
His 416 | - | expression tag |
His 417 | - | expression tag |
His 418 | - | expression tag |
His 419 | - | expression tag |
His 420 | - | expression tag |
His 421 | - | expression tag |
His 422 | - | expression tag |
His 423 | - | expression tag |
His 424 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 190050.1 | |
All* | Total formula weight | 190050.1 |