8XVH
Cryo-EM structure of ETBR bound with Endothelin1
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 25 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. ClccwCqleVlfqgphhhHhhhhhH |
| Chain | Residue | Details |
| R | CYS400-HIS424 |
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV |
| Chain | Residue | Details |
| R | ILE187-VAL203 |
| site_id | PS00270 |
| Number of Residues | 15 |
| Details | ENDOTHELIN Endothelin family signature. CsCsslmDkeCvyFC |
| Chain | Residue | Details |
| T | CYS1-CYS15 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| R | TYR102-ILE126 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 57 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| R | TYR127-ASN137 | |
| R | ASP198-THR218 | |
| R | THR297-THR324 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| R | ILE138-LEU163 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 49 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| R | ALA164-LYS175 | |
| R | THR244-THR271 | |
| R | ASN351-SER362 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU176-ILE197 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| R | ALA219-ILE243 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| R | ALA272-MET296 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL325-TYR350 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | PHE363-VAL389 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P28088 |
| Chain | Residue | Details |
| R | SER305 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:9261180 |
| Chain | Residue | Details |
| R | CYS402 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| R | CYS403 | |
| R | CYS405 |
