8XV7

Crystal structure of TTD-PHD domain of UHRF1 in complex with hStella peptide (residues 75-121)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	E3 ubiquitin-protein ligase UHRF1	polymer	229	26456.9	4	UniProt (Q96T88) Pfam (PF12148) Pfam (PF00628)	Homo sapiens (human)	Inverted CCAAT box-binding protein of 90 kDa,Nuclear protein 95,Nuclear zinc finger protein Np95,HuNp95,hNp95,RING finger protein 106,RING-type E3 ubiquitin transferase UHRF1,Transcription factor ICBP90,Ubiquitin-like PHD and RING finger domain-containing protein 1,hUHRF1,Ubiquitin-like-containing PHD and RING finger domains protein 1
2	B, D, F, H (B, D, F, H)	Developmental pluripotency-associated protein 3	polymer	47	5683.6	4	UniProt (Q6W0C5) Pfam (PF15549)	Homo sapiens	Stella-related protein
3	I, J, K, O, P... (A, C, E, F, G)	ZINC ION	non-polymer		65.4	14	Chemie (ZN)
4	L, M (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	N (A)	ACETIC ACID	non-polymer		60.1	1	Chemie (ACY)
6	AA, BA, CA, DA, EA... (B, C, D, E, F...)	water	water		18.0	370	Chemie (HOH)

Sequence modifications

A, C, E, G: 134 - 366 (UniProt: Q96T88)

PDB	External Database	Details
Gly 129	-	expression tag
Pro 130	-	expression tag
Leu 131	-	expression tag
Gly 132	-	expression tag
Ser 133	-	expression tag
-	Ser 165	deletion
-	Arg 166	deletion
-	Asp 167	deletion
-	Glu 168	deletion
-	Pro 169	deletion
-	Cys 170	deletion
-	Ser 171	deletion
-	Ser 172	deletion
-	Thr 173	deletion

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	128562.0
Non-Polymers*	Number of molecules	17
	Total formula weight	1160.0
All*	Total formula weight	129721.9

*Water molecules are not included.