8XQC
Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated PAF15 and hemimethylated DNA analog
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA (cytosine-5)-methyltransferase 1 | polymer | 1271 | 143559.5 | 1 | UniProt (P26358) Pfam (PF12047) Pfam (PF02008) Pfam (PF01426) Pfam (PF00145) | Homo sapiens (human) | Dnmt1,CXXC-type zinc finger protein 9,DNA methyltransferase HsaI,DNA MTase HsaI,M.HsaI,MCMT |
| 2 | B (B) | DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3') | polymer | 12 | 3725.5 | 1 | synthetic construct | ||
| 3 | C (C) | DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3') | polymer | 12 | 3679.5 | 1 | synthetic construct | ||
| 4 | D (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 5 | E, F (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: 351 - 1616 (UniProt: P26358)
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | - | expression tag |
| Pro 347 | - | expression tag |
| Pro 348 | - | expression tag |
| Thr 349 | - | expression tag |
| Thr 350 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 150964.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 515.2 | |
| All* | Total formula weight | 151479.7 |
