8XLF

Structure of chimeric RyR

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, B, C, D)	Ryanodine receptor 1	polymer	5037	565880.5	4	UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119)	Oryctolagus cuniculus (rabbit)	RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor
2	B, E, H, K (L, I, J, K)	Calmodulin-1	polymer	148	16491.2	4	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (human)
3	C, F, I, L (H, E, F, G)	Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	107	11667.3	4	UniProt (P68106) Pfam (PF00254)	Homo sapiens (human)	PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12
4	M, Q, U, Y (A, B, C, D)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
5	N, R, V, Z (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	AA, O, S, W (D, A, B, C)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	4	Chemie (ATP)
7	BA, P, T, X (D, A, B, C)	CAFFEINE	non-polymer		194.2	4	Chemie (CFF)

Sequence modifications

A, B, C, D: 1 - 5037 (UniProt: P11716)

PDB	External Database	Details
Lys 4563	Arg 4563	engineered mutation
Tyr 4564	Phe 4564	engineered mutation
Ile 4657	Cys 4657	engineered mutation
Ser 4792	Leu 4792	engineered mutation

L, I, J, K: 1 - 148 (UniProt: P0DP23)

PDB	External Database	Details
Ala 32	Glu 32	engineered mutation
Ala 68	Glu 68	engineered mutation
Ala 105	Glu 105	engineered mutation
Ala 141	Glu 141	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	2376156.1
Non-Polymers*	Number of molecules	16
	Total formula weight	3227.4
All*	Total formula weight	2379383.5

*Water molecules are not included.