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8XLF

Structure of chimeric RyR

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003151biological_processoutflow tract morphogenesis
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006936biological_processmuscle contraction
A0006941biological_processstriated muscle contraction
A0008144molecular_functionobsolete drug binding
A0014802cellular_componentterminal cisterna
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0015278molecular_functionintracellularly gated calcium channel activity
A0015643molecular_functiontoxic substance binding
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030018cellular_componentZ disc
A0031090cellular_componentorganelle membrane
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034704cellular_componentcalcium channel complex
A0035381molecular_functionATP-gated ion channel activity
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043931biological_processossification involved in bone maturation
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0048741biological_processskeletal muscle fiber development
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071313biological_processcellular response to caffeine
A0097718molecular_functiondisordered domain specific binding
A1990425cellular_componentryanodine receptor complex
B0000166molecular_functionnucleotide binding
B0003151biological_processoutflow tract morphogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006936biological_processmuscle contraction
B0006941biological_processstriated muscle contraction
B0008144molecular_functionobsolete drug binding
B0014802cellular_componentterminal cisterna
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0015278molecular_functionintracellularly gated calcium channel activity
B0015643molecular_functiontoxic substance binding
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030018cellular_componentZ disc
B0031090cellular_componentorganelle membrane
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034704cellular_componentcalcium channel complex
B0035381molecular_functionATP-gated ion channel activity
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043931biological_processossification involved in bone maturation
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0048741biological_processskeletal muscle fiber development
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071277biological_processcellular response to calcium ion
B0071313biological_processcellular response to caffeine
B0097718molecular_functiondisordered domain specific binding
B1990425cellular_componentryanodine receptor complex
C0000166molecular_functionnucleotide binding
C0003151biological_processoutflow tract morphogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006936biological_processmuscle contraction
C0006941biological_processstriated muscle contraction
C0008144molecular_functionobsolete drug binding
C0014802cellular_componentterminal cisterna
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0015278molecular_functionintracellularly gated calcium channel activity
C0015643molecular_functiontoxic substance binding
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030018cellular_componentZ disc
C0031090cellular_componentorganelle membrane
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034704cellular_componentcalcium channel complex
C0035381molecular_functionATP-gated ion channel activity
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043931biological_processossification involved in bone maturation
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048741biological_processskeletal muscle fiber development
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071313biological_processcellular response to caffeine
C0097718molecular_functiondisordered domain specific binding
C1990425cellular_componentryanodine receptor complex
D0000166molecular_functionnucleotide binding
D0003151biological_processoutflow tract morphogenesis
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005245molecular_functionvoltage-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005790cellular_componentsmooth endoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006936biological_processmuscle contraction
D0006941biological_processstriated muscle contraction
D0008144molecular_functionobsolete drug binding
D0014802cellular_componentterminal cisterna
D0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0015278molecular_functionintracellularly gated calcium channel activity
D0015643molecular_functiontoxic substance binding
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0030018cellular_componentZ disc
D0031090cellular_componentorganelle membrane
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034704cellular_componentcalcium channel complex
D0035381molecular_functionATP-gated ion channel activity
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043588biological_processskin development
D0043931biological_processossification involved in bone maturation
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0048741biological_processskeletal muscle fiber development
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071277biological_processcellular response to calcium ion
D0071313biological_processcellular response to caffeine
D0097718molecular_functiondisordered domain specific binding
D1990425cellular_componentryanodine receptor complex
E0002027biological_processregulation of heart rate
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005102molecular_functionsignaling receptor binding
E0005246molecular_functioncalcium channel regulator activity
E0005515molecular_functionprotein binding
E0005528molecular_functionFK506 binding
E0005737cellular_componentcytoplasm
E0006458biological_process'de novo' protein folding
E0006939biological_processsmooth muscle contraction
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0009749biological_processresponse to glucose
E0010459biological_processnegative regulation of heart rate
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016529cellular_componentsarcoplasmic reticulum
E0016853molecular_functionisomerase activity
E0019227biological_processneuronal action potential propagation
E0019722biological_processcalcium-mediated signaling
E0019855molecular_functioncalcium channel inhibitor activity
E0030018cellular_componentZ disc
E0030073biological_processinsulin secretion
E0033017cellular_componentsarcoplasmic reticulum membrane
E0034704cellular_componentcalcium channel complex
E0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
E0042026biological_processprotein refolding
E0042098biological_processT cell proliferation
E0044325molecular_functiontransmembrane transporter binding
E0050849biological_processnegative regulation of calcium-mediated signaling
E0051209biological_processrelease of sequestered calcium ion into cytosol
E0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
E0051284biological_processpositive regulation of sequestering of calcium ion
E0051604biological_processprotein maturation
E0051775biological_processresponse to redox state
E0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
F0002027biological_processregulation of heart rate
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005102molecular_functionsignaling receptor binding
F0005246molecular_functioncalcium channel regulator activity
F0005515molecular_functionprotein binding
F0005528molecular_functionFK506 binding
F0005737cellular_componentcytoplasm
F0006458biological_process'de novo' protein folding
F0006939biological_processsmooth muscle contraction
F0007204biological_processpositive regulation of cytosolic calcium ion concentration
F0009749biological_processresponse to glucose
F0010459biological_processnegative regulation of heart rate
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016529cellular_componentsarcoplasmic reticulum
F0016853molecular_functionisomerase activity
F0019227biological_processneuronal action potential propagation
F0019722biological_processcalcium-mediated signaling
F0019855molecular_functioncalcium channel inhibitor activity
F0030018cellular_componentZ disc
F0030073biological_processinsulin secretion
F0033017cellular_componentsarcoplasmic reticulum membrane
F0034704cellular_componentcalcium channel complex
F0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
F0042026biological_processprotein refolding
F0042098biological_processT cell proliferation
F0044325molecular_functiontransmembrane transporter binding
F0050849biological_processnegative regulation of calcium-mediated signaling
F0051209biological_processrelease of sequestered calcium ion into cytosol
F0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
F0051284biological_processpositive regulation of sequestering of calcium ion
F0051604biological_processprotein maturation
F0051775biological_processresponse to redox state
F0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
G0002027biological_processregulation of heart rate
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005102molecular_functionsignaling receptor binding
G0005246molecular_functioncalcium channel regulator activity
G0005515molecular_functionprotein binding
G0005528molecular_functionFK506 binding
G0005737cellular_componentcytoplasm
G0006458biological_process'de novo' protein folding
G0006939biological_processsmooth muscle contraction
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0009749biological_processresponse to glucose
G0010459biological_processnegative regulation of heart rate
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0016853molecular_functionisomerase activity
G0019227biological_processneuronal action potential propagation
G0019722biological_processcalcium-mediated signaling
G0019855molecular_functioncalcium channel inhibitor activity
G0030018cellular_componentZ disc
G0030073biological_processinsulin secretion
G0033017cellular_componentsarcoplasmic reticulum membrane
G0034704cellular_componentcalcium channel complex
G0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
G0042026biological_processprotein refolding
G0042098biological_processT cell proliferation
G0044325molecular_functiontransmembrane transporter binding
G0050849biological_processnegative regulation of calcium-mediated signaling
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051284biological_processpositive regulation of sequestering of calcium ion
G0051604biological_processprotein maturation
G0051775biological_processresponse to redox state
G0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
H0002027biological_processregulation of heart rate
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005102molecular_functionsignaling receptor binding
H0005246molecular_functioncalcium channel regulator activity
H0005515molecular_functionprotein binding
H0005528molecular_functionFK506 binding
H0005737cellular_componentcytoplasm
H0006458biological_process'de novo' protein folding
H0006939biological_processsmooth muscle contraction
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0009749biological_processresponse to glucose
H0010459biological_processnegative regulation of heart rate
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016529cellular_componentsarcoplasmic reticulum
H0016853molecular_functionisomerase activity
H0019227biological_processneuronal action potential propagation
H0019722biological_processcalcium-mediated signaling
H0019855molecular_functioncalcium channel inhibitor activity
H0030018cellular_componentZ disc
H0030073biological_processinsulin secretion
H0033017cellular_componentsarcoplasmic reticulum membrane
H0034704cellular_componentcalcium channel complex
H0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
H0042026biological_processprotein refolding
H0042098biological_processT cell proliferation
H0044325molecular_functiontransmembrane transporter binding
H0050849biological_processnegative regulation of calcium-mediated signaling
H0051209biological_processrelease of sequestered calcium ion into cytosol
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051284biological_processpositive regulation of sequestering of calcium ion
H0051604biological_processprotein maturation
H0051775biological_processresponse to redox state
H0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
I0000086biological_processG2/M transition of mitotic cell cycle
I0000922cellular_componentspindle pole
I0002027biological_processregulation of heart rate
I0005246molecular_functioncalcium channel regulator activity
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005876cellular_componentspindle microtubule
I0005886cellular_componentplasma membrane
I0005929cellular_componentcilium
I0007186biological_processG protein-coupled receptor signaling pathway
I0007259biological_processcell surface receptor signaling pathway via JAK-STAT
I0008076cellular_componentvoltage-gated potassium channel complex
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0021762biological_processsubstantia nigra development
I0030017cellular_componentsarcomere
I0030672cellular_componentsynaptic vesicle membrane
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031982cellular_componentvesicle
I0032465biological_processregulation of cytokinesis
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035458biological_processcellular response to interferon-beta
I0042995cellular_componentcell projection
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0044305cellular_componentcalyx of Held
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050848biological_processregulation of calcium-mediated signaling
I0051592biological_processresponse to calcium ion
I0055117biological_processregulation of cardiac muscle contraction
I0060291biological_processlong-term synaptic potentiation
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0072542molecular_functionprotein phosphatase activator activity
I0097225cellular_componentsperm midpiece
I0097720biological_processcalcineurin-mediated signaling
I0098901biological_processregulation of cardiac muscle cell action potential
I0099523cellular_componentpresynaptic cytosol
I0140056biological_processorganelle localization by membrane tethering
I0140238biological_processpresynaptic endocytosis
I0141110molecular_functiontransporter inhibitor activity
I1901842biological_processnegative regulation of high voltage-gated calcium channel activity
I1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
I1902494cellular_componentcatalytic complex
I1905913biological_processnegative regulation of calcium ion export across plasma membrane
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J0000086biological_processG2/M transition of mitotic cell cycle
J0000922cellular_componentspindle pole
J0002027biological_processregulation of heart rate
J0005246molecular_functioncalcium channel regulator activity
J0005509molecular_functioncalcium ion binding
J0005513biological_processdetection of calcium ion
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005876cellular_componentspindle microtubule
J0005886cellular_componentplasma membrane
J0005929cellular_componentcilium
J0007186biological_processG protein-coupled receptor signaling pathway
J0007259biological_processcell surface receptor signaling pathway via JAK-STAT
J0008076cellular_componentvoltage-gated potassium channel complex
J0010856molecular_functionadenylate cyclase activator activity
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016240biological_processautophagosome membrane docking
J0019855molecular_functioncalcium channel inhibitor activity
J0019901molecular_functionprotein kinase binding
J0021762biological_processsubstantia nigra development
J0030017cellular_componentsarcomere
J0030672cellular_componentsynaptic vesicle membrane
J0031432molecular_functiontitin binding
J0031514cellular_componentmotile cilium
J0031982cellular_componentvesicle
J0032465biological_processregulation of cytokinesis
J0032991cellular_componentprotein-containing complex
J0034704cellular_componentcalcium channel complex
J0035458biological_processcellular response to interferon-beta
J0042995cellular_componentcell projection
J0043209cellular_componentmyelin sheath
J0043539molecular_functionprotein serine/threonine kinase activator activity
J0044305cellular_componentcalyx of Held
J0044325molecular_functiontransmembrane transporter binding
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046872molecular_functionmetal ion binding
J0048306molecular_functioncalcium-dependent protein binding
J0050848biological_processregulation of calcium-mediated signaling
J0051592biological_processresponse to calcium ion
J0055117biological_processregulation of cardiac muscle contraction
J0060291biological_processlong-term synaptic potentiation
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
J0071346biological_processcellular response to type II interferon
J0072542molecular_functionprotein phosphatase activator activity
J0097225cellular_componentsperm midpiece
J0097720biological_processcalcineurin-mediated signaling
J0098901biological_processregulation of cardiac muscle cell action potential
J0099523cellular_componentpresynaptic cytosol
J0140056biological_processorganelle localization by membrane tethering
J0140238biological_processpresynaptic endocytosis
J0141110molecular_functiontransporter inhibitor activity
J1901842biological_processnegative regulation of high voltage-gated calcium channel activity
J1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
J1902494cellular_componentcatalytic complex
J1905913biological_processnegative regulation of calcium ion export across plasma membrane
J1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
K0000086biological_processG2/M transition of mitotic cell cycle
K0000922cellular_componentspindle pole
K0002027biological_processregulation of heart rate
K0005246molecular_functioncalcium channel regulator activity
K0005509molecular_functioncalcium ion binding
K0005513biological_processdetection of calcium ion
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005876cellular_componentspindle microtubule
K0005886cellular_componentplasma membrane
K0005929cellular_componentcilium
K0007186biological_processG protein-coupled receptor signaling pathway
K0007259biological_processcell surface receptor signaling pathway via JAK-STAT
K0008076cellular_componentvoltage-gated potassium channel complex
K0010856molecular_functionadenylate cyclase activator activity
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016020cellular_componentmembrane
K0016240biological_processautophagosome membrane docking
K0019855molecular_functioncalcium channel inhibitor activity
K0019901molecular_functionprotein kinase binding
K0021762biological_processsubstantia nigra development
K0030017cellular_componentsarcomere
K0030672cellular_componentsynaptic vesicle membrane
K0031432molecular_functiontitin binding
K0031514cellular_componentmotile cilium
K0031982cellular_componentvesicle
K0032465biological_processregulation of cytokinesis
K0032991cellular_componentprotein-containing complex
K0034704cellular_componentcalcium channel complex
K0035458biological_processcellular response to interferon-beta
K0042995cellular_componentcell projection
K0043209cellular_componentmyelin sheath
K0043539molecular_functionprotein serine/threonine kinase activator activity
K0044305cellular_componentcalyx of Held
K0044325molecular_functiontransmembrane transporter binding
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0048306molecular_functioncalcium-dependent protein binding
K0050848biological_processregulation of calcium-mediated signaling
K0051592biological_processresponse to calcium ion
K0055117biological_processregulation of cardiac muscle contraction
K0060291biological_processlong-term synaptic potentiation
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0071346biological_processcellular response to type II interferon
K0072542molecular_functionprotein phosphatase activator activity
K0097225cellular_componentsperm midpiece
K0097720biological_processcalcineurin-mediated signaling
K0098901biological_processregulation of cardiac muscle cell action potential
K0099523cellular_componentpresynaptic cytosol
K0140056biological_processorganelle localization by membrane tethering
K0140238biological_processpresynaptic endocytosis
K0141110molecular_functiontransporter inhibitor activity
K1901842biological_processnegative regulation of high voltage-gated calcium channel activity
K1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
K1902494cellular_componentcatalytic complex
K1905913biological_processnegative regulation of calcium ion export across plasma membrane
K1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
L0000086biological_processG2/M transition of mitotic cell cycle
L0000922cellular_componentspindle pole
L0002027biological_processregulation of heart rate
L0005246molecular_functioncalcium channel regulator activity
L0005509molecular_functioncalcium ion binding
L0005513biological_processdetection of calcium ion
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005876cellular_componentspindle microtubule
L0005886cellular_componentplasma membrane
L0005929cellular_componentcilium
L0007186biological_processG protein-coupled receptor signaling pathway
L0007259biological_processcell surface receptor signaling pathway via JAK-STAT
L0008076cellular_componentvoltage-gated potassium channel complex
L0010856molecular_functionadenylate cyclase activator activity
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0016020cellular_componentmembrane
L0016240biological_processautophagosome membrane docking
L0019855molecular_functioncalcium channel inhibitor activity
L0019901molecular_functionprotein kinase binding
L0021762biological_processsubstantia nigra development
L0030017cellular_componentsarcomere
L0030672cellular_componentsynaptic vesicle membrane
L0031432molecular_functiontitin binding
L0031514cellular_componentmotile cilium
L0031982cellular_componentvesicle
L0032465biological_processregulation of cytokinesis
L0032991cellular_componentprotein-containing complex
L0034704cellular_componentcalcium channel complex
L0035458biological_processcellular response to interferon-beta
L0042995cellular_componentcell projection
L0043209cellular_componentmyelin sheath
L0043539molecular_functionprotein serine/threonine kinase activator activity
L0044305cellular_componentcalyx of Held
L0044325molecular_functiontransmembrane transporter binding
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0048306molecular_functioncalcium-dependent protein binding
L0050848biological_processregulation of calcium-mediated signaling
L0051592biological_processresponse to calcium ion
L0055117biological_processregulation of cardiac muscle contraction
L0060291biological_processlong-term synaptic potentiation
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
L0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
L0071346biological_processcellular response to type II interferon
L0072542molecular_functionprotein phosphatase activator activity
L0097225cellular_componentsperm midpiece
L0097720biological_processcalcineurin-mediated signaling
L0098901biological_processregulation of cardiac muscle cell action potential
L0099523cellular_componentpresynaptic cytosol
L0140056biological_processorganelle localization by membrane tethering
L0140238biological_processpresynaptic endocytosis
L0141110molecular_functiontransporter inhibitor activity
L1901842biological_processnegative regulation of high voltage-gated calcium channel activity
L1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
L1902494cellular_componentcatalytic complex
L1905913biological_processnegative regulation of calcium ion export across plasma membrane
L1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
LASP21
LALA68
IASP21
IASP23
IASP25
ITHR27
IALA32
IASP57
IASP59
IASN61
ITHR63
LASP23
IALA68
JASP21
JASP23
JASP25
JTHR27
JALA32
JASP57
JASP59
JASN61
JTHR63
LASP25
JALA68
KASP21
KASP23
KASP25
KTHR27
KALA32
KASP57
KASP59
KASN61
KTHR63
LTHR27
KALA68
LALA32
LASP57
LASP59
LASN61
LTHR63

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:29724949, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03, ECO:0007744|PDB:6CNN, ECO:0007744|PDB:6CNO
ChainResidueDetails
LASP94
IALA105
JASP94
JASP96
JASN98
JTYR100
JALA105
KASP94
KASP96
KASN98
KTYR100
LASP96
KALA105
LASN98
LTYR100
LALA105
IASP94
IASP96
IASN98
ITYR100

site_idSWS_FT_FI3
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
LASP130
IALA141
JASP130
JASP132
JASP134
JGLN136
JALA141
KASP130
KASP132
KASP134
KGLN136
LASP132
KALA141
LASP134
LGLN136
LALA141
IASP130
IASP132
IASP134
IGLN136

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
LALA2
IALA2
JALA2
KALA2

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
LLYS22
ILYS22
JLYS22
KLYS22

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
LTHR45
ITHR45
JTHR45
KTHR45

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
LSER82
ISER82
JSER82
KSER82

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
LLYS95
ILYS95
JLYS95
KLYS95

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
LTYR100
ITYR100
JTYR100
KTYR100

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
LSER102
DGLU3893
DGLU3967
DTHR5001
ISER102
JSER102
KSER102
BGLU3967
BTHR5001
CGLU3893
CGLU3967
CTHR5001

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
LTHR111
DLYS4211
DMET4954
DTHR4979
ITHR111
JTHR111
KTHR111
BMET4954
BTHR4979
CLYS4211
CMET4954
CTHR4979

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
LLYS116
ILYS116
JLYS116
KLYS116

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
LTYR139
DSER1338
DSER2345
DSER4470
ITYR139
JTYR139
KTYR139
BSER2345
BSER4470
CSER1338
CSER2345
CSER4470

site_idSWS_FT_FI14
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
LLYS22
BSER2843
ILYS22
DSER2843
JLYS22
KLYS22

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:10601232, ECO:0000269|PubMed:11562475, ECO:0000269|PubMed:22036948
ChainResidueDetails
ACYS3635
BCYS3635
CCYS3635
DCYS3635

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
ATHR4466
BTHR4466
CTHR4466
DTHR4466

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ATYR4863
BTYR4863
CTYR4863
DTYR4863

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ASER4866
BSER4866
CSER4866
DSER4866

237735

PDB entries from 2025-06-18

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