8XJO
U46619 bound Thromboxane A2 receptor-Gq Protein Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Engineered miniGq | polymer | 246 | 28305.2 | 1 | synthetic construct | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 376 | 40845.6 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | Antibody fragment scFv16 | polymer | 255 | 27374.4 | 1 | synthetic construct | ||
| 5 | E (R) | Fusion tag,Thromboxane A2 receptor,LgBiT | polymer | 559 | 61019.8 | 1 | UniProt (P21731) Pfam (PF00001) | synthetic construct (human) | TXA2-R,Prostanoid TP receptor |
| 6 | F (R) | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid | non-polymer | 350.5 | 1 | Chemie (PUC) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -52 - 0 (PDB: 8XJO)
R: 1 - 331 (UniProt: P21731)
R: 332 - 506 (PDB: 8XJO)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
R: 1 - 331 (UniProt: P21731)
R: 332 - 506 (PDB: 8XJO)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 165406.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 350.5 | |
| All* | Total formula weight | 165756.7 |
