8XB2
Structure of radafaxine-bound state of the human Norepinephrine Transporter
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter | polymer | 1244 | 138697.0 | 1 | UniProt (P0AEX9) UniProt (P23975) Pfam (PF01547) Pfam (PF00209) | Homo sapiens (human) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Norepinephrine transporter,NET,Solute carrier family 6 member 2 |
| 2 | B (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 3 | C (A) | Radafaxine | non-polymer | 255.7 | 1 | Chemie (YNT) |
Sequence modifications
A: -623 - -328 (PDB: 8XB2)
A: -324 - 41 (UniProt: P0AEX9)
A: 54 - 617 (UniProt: P23975)
| PDB | External Database | Details |
|---|---|---|
| Gly -327 | - | linker |
| Ser -326 | - | linker |
| Met -325 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Val -13 | Ala 338 | conflict |
| Gly 42 | - | linker |
| Gly 43 | - | linker |
| Leu 44 | - | linker |
| Glu 45 | - | linker |
| Val 46 | - | linker |
| Leu 47 | - | linker |
| Phe 48 | - | linker |
| Gln 49 | - | linker |
| Gly 50 | - | linker |
| Pro 51 | - | linker |
| Glu 52 | - | linker |
| Phe 53 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 190 | Leu 191 | conflict |
| Gly 190 | Asn 192 | conflict |
| Val 190 | Gly 193 | conflict |
| Ala 190 | Ser 194 | conflict |
| Met 190 | Val 195 | conflict |
| Pro 190 | Leu 196 | conflict |
| Ala 190 | Asn 198 | conflict |
| Glu 190 | His 199 | conflict |
| Asp 190 | Thr 200 | conflict |
| Asp 190 | Lys 201 | conflict |
| Val 190 | - | insertion |
| Val 190 | - | insertion |
| Gly 190 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 138697.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 476.9 | |
| All* | Total formula weight | 139174.0 |
