8XB2

Structure of radafaxine-bound state of the human Norepinephrine Transporter

Summary for 8XB2

• Entry DOI: 10.2210/pdb8xb2/pdb
• EMDB information: 38208
• Descriptor: GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol (3 entities in total)
• Functional Keywords: antidepressant, bupropion, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 139173.97

Authors

Wu, J.X.,Ji, W.M. (deposition date: 2023-12-05, release date: 2024-07-10)

• Primary citation: Ji, W.M.,Wu, J.X.; Substrate binding and inhibition mechanism of norepinephrine transporter; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.04 Å)