8X7H
Crystal structure of the ternary complex of GID4-PROTAC(NEP162)-BRD4(BD1).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Glucose-induced degradation protein 4 homolog | polymer | 167 | 19604.8 | 4 | UniProt (Q8IVV7) Pfam (PF09783) | Homo sapiens (human) | Vacuolar import and degradation protein 24 homolog |
| 2 | B, D, F, H (B, D, F, H) | Bromodomain-containing protein 4 | polymer | 126 | 14938.2 | 4 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 3 | I, K, P, Q (A, C, E, G) | ~{N}-[4-[6-[3-[4-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoyl]piperazin-1-yl]propoxy]-1~{H}-benzimidazol-2-yl]cyclohexyl]-2-(1~{H}-indol-2-ylmethylamino)ethanamide | non-polymer | 926.6 | 4 | Chemie (YBI) | |||
| 4 | J, L, M, N, O... (B, D, G, H) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | AA, BA, U, V, W... (G, H, A, B, C...) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 124 - 289 (UniProt: Q8IVV7)
B, D, F, H: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 138171.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4443.0 | |
| All* | Total formula weight | 142614.8 |
