8X7H
Crystal structure of the ternary complex of GID4-PROTAC(NEP162)-BRD4(BD1).
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
| Chain | Residue | Details |
| B | ALA80-TYR139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331 |
| Chain | Residue | Details |
| B | ASN140 | |
| G | GLN132 | |
| G | GLU237 | |
| G | TYR258 | |
| D | ASN140 | |
| F | ASN140 | |
| H | ASN140 | |
| C | GLU237 | |
| C | TYR258 | |
| E | GLN132 | |
| E | GLU237 | |
| E | TYR258 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS99 | |
| D | LYS99 | |
| F | LYS99 | |
| H | LYS99 |
