8X7A
Treprostinil bound Prostacyclin Receptor G protein complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,GNAS complex locus | polymer | 249 | 29068.9 | 1 | UniProt (A0A590UJY2) Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38613.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody35 | polymer | 134 | 14714.3 | 1 | Homo sapiens | ||
| 5 | E (R) | Prostacyclin receptor | polymer | 386 | 40989.9 | 1 | UniProt (P43119) Pfam (PF00001) | Homo sapiens (human) | Prostaglandin I2 receptor,PGI receptor,PGI2 receptor,Prostanoid IP receptor |
| 6 | F (R) | Treprostinil | non-polymer | 390.5 | 1 | Chemie (Y9J) |
Sequence modifications
A: 5 - 203 (PDB: 8X7A)
A: 204 - 384 (UniProt: A0A590UJY2)
B: 2 - 340 (UniProt: P62873)
A: 204 - 384 (UniProt: A0A590UJY2)
| PDB | External Database | Details |
|---|---|---|
| Ala 226 | Gly 69 | conflict |
| Asp 249 | Ala 92 | conflict |
| Asp 252 | Ser 95 | conflict |
| - | Met 98 | deletion |
| - | Val 99 | deletion |
| - | Ile 100 | deletion |
| - | Arg 101 | deletion |
| - | Glu 102 | deletion |
| - | Asp 103 | deletion |
| - | Asn 104 | deletion |
| - | Gln 105 | deletion |
| - | Thr 106 | deletion |
| - | Asn 107 | deletion |
| Ser 356 | Ala 209 | conflict |
| Ala 362 | Ile 215 | conflict |
| Ile 365 | Val 218 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 131247.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 390.5 | |
| All* | Total formula weight | 131638.0 |
