8X79
MRE-269 bound Prostacyclin Receptor G protein complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,GNAS complex locus,GNAS complex locus | polymer | 249 | 29068.9 | 1 | UniProt (A0A590UJY2) Pfam (PF00503) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38613.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody35 | polymer | 134 | 14714.3 | 1 | Homo sapiens | ||
5 | R | Prostacyclin receptor | polymer | 386 | 40989.9 | 1 | UniProt (P43119) Pfam (PF00001) In PDB | Homo sapiens (human) | Prostaglandin I2 receptor,PGI receptor,PGI2 receptor,Prostanoid IP receptor |
6 | R | 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid | non-polymer | 419.5 | 1 | Chemie (Y9Q) |
Sequence modifications
A: 5 - 203 (PDB: 8X79)
A: 204 - 384 (UniProt: A0A590UJY2)
B: 2 - 340 (UniProt: P62873)
A: 204 - 384 (UniProt: A0A590UJY2)
PDB | External Database | Details |
---|---|---|
Ala 226 | Gly 69 | conflict |
Asp 249 | Ala 92 | conflict |
Asp 252 | Ser 95 | conflict |
- | Met 98 | deletion |
- | Val 99 | deletion |
- | Ile 100 | deletion |
- | Arg 101 | deletion |
- | Glu 102 | deletion |
- | Asp 103 | deletion |
- | Asn 104 | deletion |
- | Gln 105 | deletion |
- | Thr 106 | deletion |
- | Asn 107 | deletion |
Ser 356 | Ala 209 | conflict |
Ala 362 | Ile 215 | conflict |
Ile 365 | Val 218 | conflict |
PDB | External Database | Details |
---|---|---|
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 131247.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 419.5 | |
All* | Total formula weight | 131667.0 |