8X6R
KRasG12C in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Isoform 2B of GTPase KRas | polymer | 170 | 19358.8 | 6 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | G, J, M, P, S... (A, B, C, D, E...) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 6 | Chemie (GDP) | |||
| 3 | H, K, N, Q, T... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 4 | I, L, O, R, U... (A, B, C, D, E...) | 1-[7-[6-ethenyl-8-ethoxy-7-(5-methyl-1~{H}-indazol-4-yl)-2-(1-methylpiperidin-4-yl)oxy-quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one | non-polymer | 623.8 | 6 | Chemie (Y9D) | |||
| 5 | AA, BA, CA, DA, Y... (C, D, E, F, A...) | water | water | 18.0 | 253 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 169 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 116153.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 6547.8 | |
| All* | Total formula weight | 122700.8 |
