8X6R
KRasG12C in complex with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005525 | molecular_function | GTP binding |
| E | 0007165 | biological_process | signal transduction |
| E | 0016020 | cellular_component | membrane |
| F | 0003924 | molecular_function | GTPase activity |
| F | 0005525 | molecular_function | GTP binding |
| F | 0007165 | biological_process | signal transduction |
| F | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 |
| Chain | Residue | Details |
| A | GLY10 | |
| C | VAL29 | |
| C | ALA59 | |
| C | ASN116 | |
| D | GLY10 | |
| D | VAL29 | |
| D | ALA59 | |
| D | ASN116 | |
| E | GLY10 | |
| E | VAL29 | |
| E | ALA59 | |
| A | VAL29 | |
| E | ASN116 | |
| F | GLY10 | |
| F | VAL29 | |
| F | ALA59 | |
| F | ASN116 | |
| A | ALA59 | |
| A | ASN116 | |
| B | GLY10 | |
| B | VAL29 | |
| B | ALA59 | |
| B | ASN116 | |
| C | GLY10 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 | |
| C | MET1 | |
| D | MET1 | |
| E | MET1 | |
| F | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17 |
| Chain | Residue | Details |
| A | THR2 | |
| B | THR2 | |
| C | THR2 | |
| D | THR2 | |
| E | THR2 | |
| F | THR2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838 |
| Chain | Residue | Details |
| A | LYS104 | |
| B | LYS104 | |
| C | LYS104 | |
| D | LYS104 | |
| E | LYS104 | |
| F | LYS104 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 |
| Chain | Residue | Details |
| A | THR35 | |
| B | THR35 | |
| C | THR35 | |
| D | THR35 | |
| E | THR35 | |
| F | THR35 |
