8X6B

Crystal structure of immune receptor PVRIG in complex with ligand Nectin-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Transmembrane protein PVRIG	polymer	141	14599.4	1	UniProt (Q6DKI7) Pfam (PF25456)	Homo sapiens (human)	CD112 receptor,CD112R,Poliovirus receptor-related immunoglobulin domain-containing protein
2	B (A)	Nectin-2	polymer	128	13950.8	1	UniProt (Q92692) Pfam (PF07686)	Homo sapiens (human)
3	C (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
4	D, E (B, A)	water	water		18.0	122	Chemie (HOH)

Sequence modifications

B: 1 - 116 (UniProt: Q6DKI7)

PDB	External Database	Details
Met -24	-	initiating methionine
Val -23	-	expression tag
Ser -22	-	expression tag
Ala -21	-	expression tag
Ile -20	-	expression tag
Val -19	-	expression tag
Leu -18	-	expression tag
Tyr -17	-	expression tag
Val -16	-	expression tag
Leu -15	-	expression tag
Leu -14	-	expression tag
Ala -13	-	expression tag
Ala -12	-	expression tag
Ala -11	-	expression tag
Ala -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Ala -7	-	expression tag
Phe -6	-	expression tag
Ala -5	-	expression tag
Ala -4	-	expression tag
Asp -3	-	expression tag
Gly -2	-	expression tag
Ile -1	-	expression tag
Gln 0	-	expression tag
Ser 89	Cys 127	engineered mutation

A: 2 - 128 (UniProt: Q92692)

PDB	External Database	Details
Met 1	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28550.2
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	28771.4

*Water molecules are not included.