8X21
HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/L74V:DNA:ETV-TP ternary complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Pol protein (Fragment) | polymer | 557 | 64019.4 | 2 | UniProt (D3XFN5) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) UniProt (by SIFTS) (P12497) In PDB | Human immunodeficiency virus 1 | |
2 | B, D | HIV-1 RT p51 subunit | polymer | 444 | 51861.5 | 2 | UniProt (P12497) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus 1 | HIV-1 reverse transcriptase p51 subunit, p51 RT |
3 | E, F | DNA/RNA (38-MER) | polymer | 38 | 11724.5 | 2 | synthetic construct | ||
4 | A, C | [[(1R,3S,5S)-3-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-methylidene-5-oxidanyl-cyclopentyl]methoxy-oxidanyl-phosphory l] phosphono hydrogen phosphate | non-polymer | 517.2 | 2 | Chemie (ET9) | |||
5 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | A, B, E, D | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
7 | water | water | 18.0 | 458 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 555 (UniProt: D3XFN5)
B, D: 1 - 428 (UniProt: P12497)
PDB | External Database | Details |
---|---|---|
Met -1 | - | initiating methionine |
Val 0 | - | expression tag |
Val 74 | Leu 173 | engineered mutation |
Phe 115 | Tyr 214 | engineered mutation |
Tyr 116 | Phe 215 | engineered mutation |
Met 151 | Gln 250 | engineered mutation |
Ser 162 | Cys 261 | engineered mutation |
Ser 280 | Cys 379 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -15 | - | expression tag |
Ala -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Ala -7 | - | expression tag |
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 162 | Cys 749 | engineered mutation |
Ser 280 | Cys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 255210.8 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1635.6 | |
All* | Total formula weight | 256846.4 |