8X21

HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/L74V:DNA:ETV-TP ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process
C	0003676	molecular_function	nucleic acid binding
C	0003964	molecular_function	RNA-directed DNA polymerase activity
C	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
C	0006278	biological_process	RNA-templated DNA biosynthetic process
D	0003964	molecular_function	RNA-directed DNA polymerase activity
D	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP110
C	ASP186
C	ASP443
C	GLU478
C	ASP498
C	ASP549
A	ASP185
A	ASP186
A	ASP443
A	GLU478
A	ASP498
A	ASP549
C	ASP110
C	ASP185

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Essential for RT p66/p51 heterodimerization => ECO:0000250

Chain	Residue	Details
A	TRP401
A	TRP414
C	TRP401
C	TRP414

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by viral protease; partial => ECO:0000250

Chain	Residue	Details
A	PHE440
C	PHE440

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