8X1S
Cryo-EM structure of human DRA (SLC26A3) bound with tenidap
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Chloride anion exchanger | polymer | 775 | 85877.8 | 2 | UniProt (P40879) Pfam (PF00916) Pfam (PF01740) | Homo sapiens (human) | DRA |
| 2 | C, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D, G (A, B) | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 510.7 | 2 | Chemie (LPE) | |||
| 4 | E, H (A, B) | 5-chloranyl-2-oxidanyl-3-thiophen-2-ylcarbonyl-indole-1-carboxamide | non-polymer | 320.8 | 2 | Chemie (I2U) |
Sequence modifications
A, B: 1 - 764 (UniProt: P40879)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| Asp -9 | - | expression tag |
| Tyr -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 171755.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1733.8 | |
| All* | Total formula weight | 173489.5 |
