8X1S
Cryo-EM structure of human DRA (SLC26A3) bound with tenidap
Functional Information from PROSITE/UniProt
| site_id | PS01130 |
| Number of Residues | 22 |
| Details | SLC26A SLC26A transporters signature. PvYGLYASffpaIIYlffGTSR |
| Chain | Residue | Details |
| A | PRO102-ARG123 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 734 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-ASP76 | |
| B | ASN279-ASP342 | |
| B | ALA396-GLN411 | |
| B | SER491-ASP701 | |
| A | THR121-HIS124 | |
| A | ARG197 | |
| A | ASN279-ASP342 | |
| A | ALA396-GLN411 | |
| A | SER491-ASP701 | |
| B | MET1-ASP76 | |
| B | THR121-HIS124 | |
| B | ARG197 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 400 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE77-LEU97 | |
| A | LEU470-ALA490 | |
| B | ILE77-LEU97 | |
| B | ILE100-GLY120 | |
| B | ILE125-VAL145 | |
| B | VAL176-LEU196 | |
| B | ILE198-ALA218 | |
| B | ASN258-ILE278 | |
| B | CYS343-LEU363 | |
| B | LEU375-THR395 | |
| B | ILE412-LEU432 | |
| A | ILE100-GLY120 | |
| B | LEU470-ALA490 | |
| A | ILE125-VAL145 | |
| A | VAL176-LEU196 | |
| A | ILE198-ALA218 | |
| A | ASN258-ILE278 | |
| A | CYS343-LEU363 | |
| A | LEU375-THR395 | |
| A | ILE412-LEU432 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 228 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | VAL98-ASP99 | |
| B | ALA433-CYS469 | |
| A | SER146-ARG175 | |
| A | VAL219-THR257 | |
| A | LYS364-GLU374 | |
| A | ALA433-CYS469 | |
| B | VAL98-ASP99 | |
| B | SER146-ARG175 | |
| B | VAL219-THR257 | |
| B | LYS364-GLU374 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22159084 |
| Chain | Residue | Details |
| A | ASN153 | |
| A | ASN161 | |
| A | ASN165 | |
| B | ASN153 | |
| B | ASN161 | |
| B | ASN165 |
