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8X16

Cryo-EM structure of adenosine receptor A3AR bound to CF101

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)
Adenosine receptor A3polymer31836214.51UniProt (P0DMS8)
Pfam (PF00001)
Homo sapiens (human)
2B
(A)
Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440445.11UniProt (P63097)
Pfam (PF00503)
Bos taurus (cattle)
3C
(B)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537915.51UniProt (P54311)
Pfam (PF00400)
Rattus norvegicus (Norway rat)Transducin beta chain 1
4D
(C)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P63212)
Pfam (PF00631)
Bos taurus (cattle)G gamma-I
5E
(H)
scFv16polymer24726277.31Mus musculus
6F
(R)
Piclidenosonnon-polymer510.31Chemie (Q8L)
Sequence modifications
A: 1 - 354 (UniProt: P63097)
PDBExternal DatabaseDetails
Ala 203Gly 203engineered mutation
Ser 326Ala 326engineered mutation
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight148713.5
Non-Polymers*Number of molecules1
Total formula weight510.3
All*Total formula weight149223.7
*Water molecules are not included.

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PDB entries from 2024-11-20

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