8WYW
Crystal structure of spleen tyrosine kinase (SYK) in complex with SKI-O-592 (free form of SKI-O-703, cevidoplenib)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase SYK | polymer | 293 | 34216.4 | 2 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase,p72-Syk |
| 2 | C, E (A, B) | SKI-O-592 | non-polymer | 473.5 | 2 | Chemie (XFB) PubChem (91754477) PubChem (118023808) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 356 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | expression tag |
| Ala 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Leu 636 | - | expression tag |
| Glu 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
| His 642 | - | expression tag |
| His 643 | - | expression tag |
| His 644 | - | expression tag |
| His 645 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68432.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1039.1 | |
| All* | Total formula weight | 69471.9 |
