8WYW

Crystal structure of spleen tyrosine kinase (SYK) in complex with SKI-O-592 (free form of SKI-O-703, cevidoplenib)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase SYK	polymer	293	34216.4	2	UniProt (P43405) Pfam (PF07714)	Homo sapiens (human)	Spleen tyrosine kinase,p72-Syk
2	C, E (A, B)	SKI-O-592	non-polymer		473.5	2	Chemie (XFB)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	F, G (A, B)	water	water		18.0	107	Chemie (HOH)

Sequence modifications

A, B: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	expression tag
Ala 354	-	expression tag
Leu 355	-	expression tag
Leu 636	-	expression tag
Glu 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag
His 644	-	expression tag
His 645	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68432.8
Non-Polymers*	Number of molecules	3
	Total formula weight	1039.1
All*	Total formula weight	69471.9

*Water molecules are not included.