8WXE

Vgamma5Vdelta1 EH TCR-CD3 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	a, b	T-cell surface glycoprotein CD3 zeta chain	polymer	195	21809.7	2	UniProt (P20963) Pfam (PF11628) Pfam (PF02189) In PDB	Homo sapiens (human)	T-cell receptor T3 zeta chain
2	d	T-cell surface glycoprotein CD3 delta chain	polymer	171	18949.5	1	UniProt (P04234) Pfam (PF16680) Pfam (PF02189) In PDB	Homo sapiens (human)	T-cell receptor T3 delta chain
3	e, f	T-cell surface glycoprotein CD3 epsilon chain	polymer	207	23174.2	2	UniProt (P07766) Pfam (PF16681) Pfam (PF02189) In PDB	Homo sapiens (human)	T-cell surface antigen T3/Leu-4 epsilon chain
4	g	T-cell surface glycoprotein CD3 gamma chain	polymer	182	20493.5	1	UniProt (P09693) Pfam (PF16680) Pfam (PF02189) In PDB	Homo sapiens (human)	T-cell receptor T3 gamma chain
5	m	Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant	polymer	307	34320.6	1	UniProt (A0A1B0GX56) UniProt (B7Z8K6) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (human)
6	n	Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1	polymer	331	37702.1	1	UniProt (P0CF51) UniProt (A0A0B4J1U4) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (human)
7	g	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)

Sequence modifications

a, b: 1 - 164 (UniProt: P20963)

PDB	External Database	Details
Ala 165	-	expression tag
Ala 166	-	expression tag
Ala 167	-	expression tag
Trp 168	-	expression tag
Ser 169	-	expression tag
His 170	-	expression tag
Pro 171	-	expression tag
Gln 172	-	expression tag
Phe 173	-	expression tag
Glu 174	-	expression tag
Lys 175	-	expression tag
Gly 176	-	expression tag
Gly 177	-	expression tag
Gly 178	-	expression tag
Ser 179	-	expression tag
Gly 180	-	expression tag
Gly 181	-	expression tag
Gly 182	-	expression tag
Ser 183	-	expression tag
Gly 184	-	expression tag
Gly 185	-	expression tag
Ser 186	-	expression tag
Ala 187	-	expression tag
Trp 188	-	expression tag
Ser 189	-	expression tag
His 190	-	expression tag
Pro 191	-	expression tag
Gln 192	-	expression tag
Phe 193	-	expression tag
Glu 194	-	expression tag
Lys 195	-	expression tag

m: -16 - 20 (PDB: 8WXE)
m: 21 - 114 (UniProt: A0A1B0GX56)

PDB	External Database	Details
Asp 115	-	linker
Pro 116	-	linker
Gly 117	-	linker
Gly 118	-	linker
Leu 119	-	linker
Asn 120	-	linker
Thr 121	-	linker
Asp 122	-	linker
Lys 123	-	linker
Leu 124	-	linker
Ile 125	-	linker
Phe 126	-	linker
Gly 127	-	linker
Lys 128	-	linker
Gly 129	-	linker
Thr 130	-	linker
Arg 131	-	linker
Val 132	-	linker
Thr 133	-	linker
Val 134	-	linker
Glu 135	-	linker
Pro 136	-	linker
Arg 137	-	linker

m: 138 - 290 (UniProt: B7Z8K6)
n: -33 - 3 (PDB: 8WXE)
n: 4 - 103 (UniProt: A0A0B4J1U4)

PDB	External Database	Details
Glu 72	Tyr 87	engineered mutation
His 86	Arg 101	engineered mutation
Gly 104	-	linker
Asn 105	-	linker
Pro 106	-	linker
Lys 107	-	linker
Thr 108	-	linker
His 109	-	linker
Tyr 110	-	linker
Tyr 111	-	linker
Lys 112	-	linker
Lys 113	-	linker
Leu 114	-	linker
Phe 115	-	linker
Gly 116	-	linker
Ser 117	-	linker
Gly 118	-	linker
Thr 119	-	linker
Thr 120	-	linker
Leu 121	-	linker
Val 122	-	linker
Val 123	-	linker
Thr 124	-	linker

n: 125 - 297 (UniProt: P0CF51)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	201433.5
Non-Polymers*	Number of molecules	1
	Total formula weight	386.7
All*	Total formula weight	201820.1

*Water molecules are not included.