8WTQ

HUMAN SQUALENE SYNTHASE IN COMPLEX WITH {1-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6-oxo-6,7,10,11-tetrahydro-5H,9H,13H-12-oxa-5,8-diaza-benzocycloundecene-8-carbonyl]-piperidin-4-yl}-acetic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Squalene synthase	polymer	340	39166.7	1	UniProt (P37268) Pfam (PF00494) In PDB	Homo sapiens (human)	SQS,SS,FPP:FPP farnesyltransferase,Farnesyl-diphosphate farnesyltransferase,Farnesyl-diphosphate farnesyltransferase 1
2	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
3	A	2-[1-[[(10~{S})-13-chloranyl-2-(2,2-dimethylpropyl)-10-(2-methoxyphenyl)-3-oxidanylidene-9-oxa-2,5-diazabicyclo[9.4.0]pentadeca-1(15),11,13-trien-5-yl]carbonyl]piperidin-4-yl]ethanoic acid	non-polymer		600.1	1	Chemie (KUO)
4		water	water		18.0	324	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	39166.7
Non-Polymers*	Number of molecules	2
	Total formula weight	695.1
All*	Total formula weight	39861.8

*Water molecules are not included.