8WTQ
HUMAN SQUALENE SYNTHASE IN COMPLEX WITH {1-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6-oxo-6,7,10,11-tetrahydro-5H,9H,13H-12-oxa-5,8-diaza-benzocycloundecene-8-carbonyl]-piperidin-4-yl}-acetic acid
Functional Information from PROSITE/UniProt
| site_id | PS01044 |
| Number of Residues | 16 |
| Details | SQUALEN_PHYTOEN_SYN_1 Squalene and phytoene synthases signature 1. YChyVAGLVGigLsrL |
| Chain | Residue | Details |
| A | TYR171-LEU186 |
| site_id | PS01045 |
| Number of Residues | 26 |
| Details | SQUALEN_PHYTOEN_SYN_2 Squalene and phytoene synthases signature 2. MGlflQkt.NIiRDYleDqqgg...ReFwP |
| Chain | Residue | Details |
| A | MET207-PRO232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | SER284-TYR304 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24531458 |
| Chain | Residue | Details |
| A | ARG52 | |
| A | ARG77 | |
| A | ARG218 | |
| A | LYS315 | |
| A | ARG317 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24531458, ECO:0007744|PDB:3WEG, ECO:0007744|PDB:3WEH |
| Chain | Residue | Details |
| A | ASP80 | |
| A | GLU83 | |
| A | ASP84 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 264 |
| Chain | Residue | Details |
| A | TYR171 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ARG218 | electrostatic stabiliser, hydrogen bond donor, promote heterolysis |
| A | ARG228 | electrostatic stabiliser, hydrogen bond donor, promote heterolysis |
| A | PHE288 | polar/non-polar interaction, steric role, van der waals interaction |
