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8WTQ

HUMAN SQUALENE SYNTHASE IN COMPLEX WITH {1-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6-oxo-6,7,10,11-tetrahydro-5H,9H,13H-12-oxa-5,8-diaza-benzocycloundecene-8-carbonyl]-piperidin-4-yl}-acetic acid

Functional Information from PROSITE/UniProt
site_idPS01044
Number of Residues16
DetailsSQUALEN_PHYTOEN_SYN_1 Squalene and phytoene synthases signature 1. YChyVAGLVGigLsrL
ChainResidueDetails
ATYR171-LEU186

site_idPS01045
Number of Residues26
DetailsSQUALEN_PHYTOEN_SYN_2 Squalene and phytoene synthases signature 2. MGlflQkt.NIiRDYleDqqgg...ReFwP
ChainResidueDetails
AMET207-PRO232

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ASER284-TYR304

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000305|PubMed:24531458
ChainResidueDetails
AARG52
AARG77
AARG218
ALYS315
AARG317

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:24531458, ECO:0007744|PDB:3WEG, ECO:0007744|PDB:3WEH
ChainResidueDetails
AASP80
AGLU83
AASP84

Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 264
ChainResidueDetails
ATYR171hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
AARG218electrostatic stabiliser, hydrogen bond donor, promote heterolysis
AARG228electrostatic stabiliser, hydrogen bond donor, promote heterolysis
APHE288polar/non-polar interaction, steric role, van der waals interaction

222624

PDB entries from 2024-07-17

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