8WPM

Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Short transient receptor potential channel 1	polymer	797	91688.2	1	UniProt (P48995) Pfam (PF08344) Pfam (PF00520)	Homo sapiens (human)	TrpC1,Transient receptor protein 1,TRP-1
2	B, C, D (B, C, D)	Short transient receptor potential channel 4	polymer	915	105158.0	3	UniProt (Q9UBN4) Pfam (PF12796) Pfam (PF00023) Pfam (PF08344) Pfam (PF00520)	Homo sapiens (human)	TrpC4,Trp-related protein 4,hTrp-4,hTrp4
3	E, G, J, M (A, B, C, D)	7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy)phenoxy]purine-2,6-dione	non-polymer		524.9	4	Chemie (PJQ)
4	F, H, K, N (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	I, L, O (B, C, D)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)

Sequence modifications

A: 1 - 793 (UniProt: P48995)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag

B, C, D: 1 - 893 (UniProt: Q9UBN4)

PDB	External Database	Details
Ser 894	-	expression tag
Arg 895	-	expression tag
Ala 896	-	expression tag
Ser 897	-	expression tag
Thr 898	-	expression tag
Val 899	-	expression tag
Pro 900	-	expression tag
Arg 901	-	expression tag
Ala 902	-	expression tag
Arg 903	-	expression tag
Asp 904	-	expression tag
Pro 905	-	expression tag
Pro 906	-	expression tag
Val 907	-	expression tag
Ala 908	-	expression tag
Thr 909	-	expression tag
Leu 910	-	expression tag
Glu 911	-	expression tag
Val 912	-	expression tag
Leu 913	-	expression tag
Phe 914	-	expression tag
Gln 915	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	407162.1
Non-Polymers*	Number of molecules	11
	Total formula weight	2481.4
All*	Total formula weight	409643.5

*Water molecules are not included.