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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8WPM

Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145

Functional Information from GO Data
ChainGOidnamespacecontents
A0005102molecular_functionsignaling receptor binding
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0015279molecular_functionstore-operated calcium channel activity
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0042438biological_processmelanin biosynthetic process
A0043235cellular_componentreceptor complex
A0046872molecular_functionmetal ion binding
A0051117molecular_functionATPase binding
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051592biological_processresponse to calcium ion
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
A1903779biological_processregulation of cardiac conduction
B0003254biological_processregulation of membrane depolarization
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0005911cellular_componentcell-cell junction
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0008013molecular_functionbeta-catenin binding
B0009986cellular_componentcell surface
B0015279molecular_functionstore-operated calcium channel activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0030863cellular_componentcortical cytoskeleton
B0032991cellular_componentprotein-containing complex
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0034704cellular_componentcalcium channel complex
B0045121cellular_componentmembrane raft
B0045296molecular_functioncadherin binding
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051899biological_processmembrane depolarization
B0055085biological_processtransmembrane transport
B0070509biological_processcalcium ion import
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0003254biological_processregulation of membrane depolarization
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0005901cellular_componentcaveola
C0005911cellular_componentcell-cell junction
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0008013molecular_functionbeta-catenin binding
C0009986cellular_componentcell surface
C0015279molecular_functionstore-operated calcium channel activity
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0030863cellular_componentcortical cytoskeleton
C0032991cellular_componentprotein-containing complex
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0034704cellular_componentcalcium channel complex
C0045121cellular_componentmembrane raft
C0045296molecular_functioncadherin binding
C0051480biological_processregulation of cytosolic calcium ion concentration
C0051899biological_processmembrane depolarization
C0055085biological_processtransmembrane transport
C0070509biological_processcalcium ion import
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0003254biological_processregulation of membrane depolarization
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005901cellular_componentcaveola
D0005911cellular_componentcell-cell junction
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0008013molecular_functionbeta-catenin binding
D0009986cellular_componentcell surface
D0015279molecular_functionstore-operated calcium channel activity
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0030863cellular_componentcortical cytoskeleton
D0032991cellular_componentprotein-containing complex
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0034704cellular_componentcalcium channel complex
D0045121cellular_componentmembrane raft
D0045296molecular_functioncadherin binding
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051899biological_processmembrane depolarization
D0055085biological_processtransmembrane transport
D0070509biological_processcalcium ion import
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
Functional Information from PROSITE/UniProt
site_idPS00962
Number of Residues12
DetailsRIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG
ChainResidueDetails
BLEU492-GLY503
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues33
DetailsIntramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues39
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues17
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues20
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues29
DetailsRepeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues26
DetailsRepeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues22
DetailsRepeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues102
DetailsIntramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues81
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues66
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues66
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues211
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues93
DetailsRepeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues66
DetailsRepeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues72
DetailsRepeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues111
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues44
DetailsRepeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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