8WMU
Structural basis of tubulin and heterocyclic podophyllotoxins complex for anticancer agents with dual-binding sites
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Detyrosinated tubulin alpha-1B chain | polymer | 440 | 48966.3 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (pig) | |
| 2 | B, D (B, D) | Tubulin beta chain | polymer | 431 | 48391.4 | 2 | UniProt (A0A8D0VN39) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (pig) | |
| 3 | E (E) | Stathmin-4 | polymer | 138 | 16282.5 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
| 4 | F (F) | Tubulin--tyrosine ligase | polymer | 380 | 43825.9 | 1 | UniProt (A0A8C9FGJ1) Pfam (PF03133) | Gallus gallus (chicken) | |
| 5 | G, P, T (A, C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 3 | Chemie (GTP) | |||
| 6 | H, M, Q (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 7 | I, R (A, C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | J (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | K (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 10 | L (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 11 | N (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 12 | O (B) | (5~{S},5~{a}~{S},8~{a}~{R},9~{R})-5-(quinolin-6-ylamino)-9-(3,4,5-trimethoxyphenyl)-5~{a},6,8~{a},9-tetrahydro-5~{H}-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one | non-polymer | 540.6 | 1 | Chemie (A1D55) | |||
| 13 | S (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 14 | U (F) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 15 | AA, V, W, X, Y... (F, A, B, C, D...) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
F: 1 - 378 (UniProt: A0A8C9FGJ1)
| PDB | External Database | Details |
|---|---|---|
| His 379 | - | expression tag |
| His 380 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 254823.9 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3667.1 | |
| All* | Total formula weight | 258491.0 |
