8WKY
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Melanocortin receptor 4 | polymer | 535 | 60197.3 | 1 | UniProt (P32245) Pfam (PF00001) In PDB | Homo sapiens (human) | MC4-R |
2 | B | N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide | polymer | 10 | 1094.3 | 1 | synthetic construct | ||
3 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
4 | A | OLEIC ACID | non-polymer | 282.5 | 6 | Chemie (OLA) | |||
5 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 16 - 222 (UniProt: P32245)
A: 1001 - 1196 (PDB: 8WKY)
A: 236 - 320 (UniProt: P32245)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Lys -10 | - | expression tag |
Thr -9 | - | expression tag |
Ile -8 | - | expression tag |
Ile -7 | - | expression tag |
Ala -6 | - | expression tag |
Leu -5 | - | expression tag |
Ser -4 | - | expression tag |
Tyr -3 | - | expression tag |
Ile -2 | - | expression tag |
Phe -1 | - | expression tag |
Cys 0 | - | expression tag |
Leu 1 | - | expression tag |
Val 2 | - | expression tag |
Phe 3 | - | expression tag |
Ala 4 | - | expression tag |
Asp 5 | - | expression tag |
Tyr 6 | - | expression tag |
Lys 7 | - | expression tag |
Asp 8 | - | expression tag |
Asp 9 | - | expression tag |
Asp 10 | - | expression tag |
Asp 11 | - | expression tag |
Ala 12 | - | expression tag |
Gly 13 | - | expression tag |
Arg 14 | - | expression tag |
Ala 15 | - | expression tag |
Val 49 | Glu 49 | engineered mutation |
Leu 97 | Asn 97 | engineered mutation |
Phe 99 | Ser 99 | engineered mutation |
Ala 131 | Ser 131 | engineered mutation |
A: 236 - 320 (UniProt: P32245)
PDB | External Database | Details |
---|---|---|
Asn 298 | Asp 298 | engineered mutation |
Glu 2000 | - | expression tag |
Phe 2001 | - | expression tag |
Leu 2002 | - | expression tag |
Glu 2003 | - | expression tag |
Val 2004 | - | expression tag |
Leu 2005 | - | expression tag |
Phe 2006 | - | expression tag |
Gln 2007 | - | expression tag |
Gly 2008 | - | expression tag |
Pro 2009 | - | expression tag |
His 2010 | - | expression tag |
His 2011 | - | expression tag |
His 2012 | - | expression tag |
His 2013 | - | expression tag |
His 2014 | - | expression tag |
His 2015 | - | expression tag |
His 2016 | - | expression tag |
His 2017 | - | expression tag |
His 2018 | - | expression tag |
His 2019 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 61291.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1734.8 | |
All* | Total formula weight | 63026.5 |