8WKY

Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004977	molecular_function	melanocortin receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIcSLLSIAVDRYFtI

Chain	Residue	Details
A	ALA135-ILE151

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"33858992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AUE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	39
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"33858992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AUE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"33858992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AUE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"33858992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AUE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	13
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"33858992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AUE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"33858992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AUE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"33858992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AUE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details