8WHL

Crystal structure of CLASP2 in complex with CENP-E

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, G (B, D, C, A)	CLIP-associating protein 2	polymer	235	26443.8	4	UniProt (O75122)	Homo sapiens (human)	Cytoplasmic linker-associated protein 2,Protein Orbit homolog 2,hOrbit2
2	C, D, F, H (F, H, G, E)	Centromere-associated protein E	polymer	66	7768.6	4	UniProt (Q02224)	Homo sapiens (human)	Centromere protein E,CENP-E,Kinesin-7,Kinesin-related protein CENPE
3	I, K (B, A)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	J (B)	MALONIC ACID	non-polymer		104.1	1	Chemie (MLA)

Sequence modifications

B, D, C, A: 1251 - 1479 (UniProt: O75122)

PDB	External Database	Details
Gly 1245	-	expression tag
Pro 1246	-	expression tag
Gly 1247	-	expression tag
Ser 1248	-	expression tag
Glu 1249	-	expression tag
Phe 1250	-	expression tag

F, H, G, E: 487 - 548 (UniProt: Q02224)

PDB	External Database	Details
Gly 483	-	expression tag
Pro 484	-	expression tag
Gly 485	-	expression tag
Ser 486	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	136849.4
Non-Polymers*	Number of molecules	3
	Total formula weight	222.1
All*	Total formula weight	137071.5

*Water molecules are not included.