8WEJ
Structure of human phagocyte NADPH oxidase in the activated state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome b-245 light chain | polymer | 195 | 21005.4 | 1 | UniProt (P13498) Pfam (PF05038) | Homo sapiens (human) | |
| 2 | B (B) | Cytochrome b-245 heavy chain | polymer | 570 | 65412.7 | 1 | UniProt (P04839) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030) | Homo sapiens (human) | |
| 3 | C (C) | Neutrophil cytosol factor 1 | polymer | 286 | 32813.3 | 1 | UniProt (P14598) Pfam (PF00787) Pfam (PF00018) | Homo sapiens (human) | |
| 4 | D (D) | Neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2), isoform CRA_a | polymer | 306 | 34978.5 | 1 | UniProt (A0A024R936) Pfam (PF13181) Pfam (PF00018) UniProt (by SIFTS) (P19878) | Homo sapiens (human) | |
| 5 | E (E) | Rac family small GTPase 1 | polymer | 192 | 21463.1 | 1 | UniProt (A0A8C8XFZ1) Pfam (PF00071) UniProt (by SIFTS) (P63000) | Homo sapiens (human) | |
| 6 | F (H) | 7D5 Fab heavy chain | polymer | 251 | 27603.9 | 1 | Mus musculus | ||
| 7 | G (L) | 7D5 Fab light chain | polymer | 236 | 26238.2 | 1 | Mus musculus | ||
| 8 | H (F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | I, J (B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 10 | K, L (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 11 | M, Q (B, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 12 | N (B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 13 | O (B) | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE | non-polymer | 787.6 | 1 | Chemie (FDA) | |||
| 14 | P (E) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 15 | R (B) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 195 (UniProt: P13498)
E: 1 - 192 (UniProt: A0A8C8XFZ1)
| PDB | External Database | Details |
|---|---|---|
| Ala 174 | Val 174 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 61 | Gln 61 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 229515.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3780.2 | |
| All* | Total formula weight | 233881.9 |
