8WEJ
Structure of human phagocyte NADPH oxidase in the activated state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome b-245 light chain | polymer | 195 | 21005.4 | 1 | UniProt (P13498) Pfam (PF05038) | Homo sapiens (human) | |
| 2 | B (B) | Cytochrome b-245 heavy chain | polymer | 570 | 65412.7 | 1 | UniProt (P04839) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030) | Homo sapiens (human) | |
| 3 | C (C) | Neutrophil cytosol factor 1 | polymer | 286 | 32813.3 | 1 | UniProt (P14598) Pfam (PF00787) Pfam (PF00018) | Homo sapiens (human) | |
| 4 | D (D) | Neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2), isoform CRA_a | polymer | 306 | 34978.5 | 1 | UniProt (A0A024R936) Pfam (PF13181) Pfam (PF00018) UniProt (by SIFTS) (P19878) | Homo sapiens (human) | |
| 5 | E (E) | Rac family small GTPase 1 | polymer | 192 | 21463.1 | 1 | UniProt (A0A8C8XFZ1) Pfam (PF00071) UniProt (by SIFTS) (P63000) | Homo sapiens (human) | |
| 6 | F (H) | 7D5 Fab heavy chain | polymer | 251 | 27603.9 | 1 | Mus musculus | ||
| 7 | G (L) | 7D5 Fab light chain | polymer | 236 | 26238.2 | 1 | Mus musculus | ||
| 8 | H (F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | I, J (B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 10 | K, L (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 11 | M, Q (B, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 12 | N (B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 13 | O (B) | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE | non-polymer | 787.6 | 1 | Chemie (FDA) PubChem (705) PubChem (439491) PubChem (446013) PubChem (9940558) | |||
| 14 | P (E) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 15 | R (B) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 195 (UniProt: P13498)
E: 1 - 192 (UniProt: A0A8C8XFZ1)
| PDB | External Database | Details |
|---|---|---|
| Ala 174 | Val 174 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 61 | Gln 61 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 229515.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3780.2 | |
| All* | Total formula weight | 233881.9 |
