8W88
Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45755.5 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody35 | polymer | 139 | 15271.9 | 1 | Lama glama | ||
| 5 | E (R) | Trace amine-associated receptor 1 | polymer | 339 | 39130.6 | 1 | UniProt (Q96RJ0) Pfam (PF00001) | Homo sapiens (human) | TaR-1,Trace amine receptor 1 |
| 6 | F, G, H (R) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
| 7 | I (R) | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine | non-polymer | 183.3 | 1 | Chemie (UJL) |
Sequence modifications
A: 0 - 393 (UniProt: P63092)
B: 15 - 353 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Ala 225 | Gly 226 | conflict |
| Ser 365 | Ala 366 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
| Gly 10 | - | expression tag |
| Ser 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Gln 14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 145934.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1343.2 | |
| All* | Total formula weight | 147278.0 |
