8W7E
Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ATP-dependent Clp protease proteolytic subunit, mitochondrial | polymer | 223 | 24324.0 | 14 | UniProt (Q16740) Pfam (PF00574) | Homo sapiens (human) | Endopeptidase Clp |
| 2 | AA, BA, O, P, Q... (M, N, A, B, C...) | 3-[(3-chlorophenyl)methyl]-6-[(4-chlorophenyl)methyl]-2,4-dihydro-1H-pyrido[2,3-c][2,7]naphthyridin-5-one | non-polymer | 450.4 | 14 | Chemie (9I3) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N: 58 - 277 (UniProt: Q16740)
| PDB | External Database | Details |
|---|---|---|
| Gly 55 | - | linker |
| Ser 56 | - | linker |
| Ser 57 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 340536.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 6305.0 | |
| All* | Total formula weight | 346841.1 |
