8W4B
The sigma-1 receptor from Xenopus laevis in complex with progesterone by co-crystallization
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sigma non-opioid intracellular receptor 1 | polymer | 233 | 25720.3 | 1 | UniProt (Q6DCU6) Pfam (PF04622) | Xenopus laevis (African clawed frog) | |
| 2 | B (A) | PROGESTERONE | non-polymer | 314.5 | 1 | Chemie (STR) PubChem (16219863) PubChem (16401562) PubChem (16757724) PubChem (18635648) PubChem (23615931) PubChem (71200542) PubChem (1807216) PubChem (1807215) PubChem (1807214) PubChem (44135692) PubChem (44275133) PubChem (44279092) PubChem (1201516) PubChem (6603959) PubChem (7004693) PubChem (54269928) PubChem (11869416) PubChem (144033743) PubChem (12303982) PubChem (12303979) PubChem (57526392) PubChem (58483135) PubChem (58766357) PubChem (58872617) PubChem (170068371) PubChem (70865784) PubChem (70987742) PubChem (70987859) PubChem (117072378) PubChem (118670641) PubChem (4920) PubChem (5994) PubChem (123410055) PubChem (92940) PubChem (638017) PubChem (657254) PubChem (1274466) PubChem (5320716) PubChem (6576615) PubChem (7048588) PubChem (7059604) PubChem (7059605) PubChem (7059606) PubChem (7092664) PubChem (7092665) PubChem (129010392) PubChem (7092666) PubChem (9948776) PubChem (11869413) PubChem (11869414) PubChem (11869415) PubChem (11876098) PubChem (11876099) PubChem (11876100) PubChem (12303971) PubChem (12303981) PubChem (12303986) PubChem (12303989) PubChem (12303992) PubChem (134688829) PubChem (135189961) PubChem (135190011) PubChem (135249041) PubChem (142168519) PubChem (142402781) PubChem (145130068) PubChem (163070289) PubChem (163070290) PubChem (163070291) PubChem (163070292) | |||
| 3 | C (A) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A: 1 - 221 (UniProt: Q6DCU6)
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Arg -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Val -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Ala 222 | - | expression tag |
| Ala 223 | - | expression tag |
| Ala 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25720.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 314.5 | |
| All* | Total formula weight | 26034.8 |
