8W4B

The sigma-1 receptor from Xenopus laevis in complex with progesterone by co-crystallization

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sigma non-opioid intracellular receptor 1	polymer	233	25720.3	1	UniProt (Q6DCU6) Pfam (PF04622) In PDB	Xenopus laevis (African clawed frog)
2	A	PROGESTERONE	non-polymer		314.5	1	Chemie (STR)
3		water	water		18.0	75	Chemie (HOH)

Sequence modifications

A: 1 - 221 (UniProt: Q6DCU6)

PDB	External Database	Details
Gly -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Arg -4	-	expression tag
Ser -3	-	expression tag
Val -2	-	expression tag
Asp -1	-	expression tag
Thr 0	-	expression tag
Ala 222	-	expression tag
Ala 223	-	expression tag
Ala 224	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	25720.3
Non-Polymers*	Number of molecules	1
	Total formula weight	314.5
All*	Total formula weight	26034.8

*Water molecules are not included.