8W1V

The beta2 adrenergic receptor bound to a bitopic ligand

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Beta-2 adrenergic receptor,Endolysin	polymer	549	62208.9	2	UniProt (P07550) UniProt (P00720) Pfam (PF00001) Pfam (PF00959)	Homo sapiens (human)	Beta-2 adrenoreceptor,Beta-2 adrenoceptor,Lysis protein,Lysozyme,Muramidase
2	C, D (D, F)	Nanobody60	polymer	125	13531.0	2		Lama glama
3	E, F (A, B)	(2S)-1-[(3-{1-[4-(4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butyl]-1H-1,2,3-triazol-4-yl}propyl)amino]-3-(2-propylphenoxy)propan-2-ol	non-polymer		581.8	2	Chemie (A1AE2)
4	G (B)	Lauryl Maltose Neopentyl Glycol	non-polymer		1005.2	1	Chemie (AV0)

Sequence modifications

A, B: 1 - 1001 (UniProt: P07550)

PDB	External Database	Details
Met -23	-	initiating methionine
Lys -22	-	expression tag
Thr -21	-	expression tag
Ile -20	-	expression tag
Ile -19	-	expression tag
Ala -18	-	expression tag
Leu -17	-	expression tag
Ser -16	-	expression tag
Tyr -15	-	expression tag
Ile -14	-	expression tag
Phe -13	-	expression tag
Cys -12	-	expression tag
Leu -11	-	expression tag
Val -10	-	expression tag
Phe -9	-	expression tag
Ala -8	-	expression tag
Asp -7	-	expression tag
Tyr -6	-	expression tag
Lys -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Ala 0	-	expression tag
Arg 16	Gly 16	conflict
Gln 27	Glu 27	conflict
Glu 187	Asn 187	engineered mutation
Tyr 231	Gln 231	conflict

A, B: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Gly 1012	Arg 12	conflict
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation
Arg 1137	Ile 137	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	151479.8
Non-Polymers*	Number of molecules	3
	Total formula weight	2168.8
All*	Total formula weight	153648.5

*Water molecules are not included.